162537-10-2

Basic information

• Product Name: N-(4-Nitrophenoxycarbonyl)-L-valine Methyl Ester
• Synonyms: N-(4-Nitrophenoxycarbonyl)-L-valine Methyl Ester;Methyl (2S)-3-Methyl-2-[[(4-nitrophenoxy)carbonyl]aMino]butanoate
• CAS NO: 162537-10-2
• Molecular Formula: C₁₃H₁₆N₂O₆
• Molecular Weight: 296.27594
• Product Categories: Amino Acids & Derivatives;Heterocycles;Intermediates
• Mol File: 162537-10-2.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 412.09°C at 760 mmHg
• Flash Point: 203.025°C
• Appearance: /
• Density: 1.264g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.531
• Solubility: Chloroform, Dichloromethane
• PKA: 8.76±0.46(Predicted)
• CAS DataBase Reference: N-(4-Nitrophenoxycarbonyl)-L-valine Methyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-Nitrophenoxycarbonyl)-L-valine Methyl Ester(162537-10-2)
• EPA Substance Registry System: N-(4-Nitrophenoxycarbonyl)-L-valine Methyl Ester(162537-10-2)

Safety Data

• Hazardous Substances Data: 162537-10-2(Hazardous Substances Data)

Usage

Chemical Properties

Light Yellowish Thick-Oil

InChI:InChI=1/C13H16N2O6/c1-8(2)11(12(16)20-3)14-13(17)21-10-6-4-9(5-7-10)15(18)19/h4-8,11H,1-3H3,(H,14,17)/t11-/m0/s1

Upstream product

• 4070-48-8 L-Valine methyl ester 
• 7693-46-1 4-Nitrophenyl chloroformate 
• 6306-52-1 L-valine methylester hydrochloride 
• 144-55-8 sodium hydrogencarbonate 
• 5070-13-3 bis-(p-nitrophenyl) carbonate 

Downstream Products

• 154248-99-4 N-((N-methyl-N-((2-isopropyl-4-thiazolyl)methyl)amino)carbonyl)-L-valine methyl ester 
• 154212-61-0 N-((N-Methyl-N-((2-isopropyl-4-thiazolyl)methyl)amino)-carbonyl)-L-valine 
• 155213-67-5 ritonavir 

Relevant articles and documents

Towards a general synthesis of di-aza-amino acids containing peptides

While the incorporation of one aza-amino acid in peptides has been proved to be beneficial for inducing a structure constraint, increasing the resistance towards proteolysis and improving the biological activity, only very rare examples of the incorporation of two or more consecutive aza-amino acids have been reported. In this work, we demonstrate that this fact is probably due to the unsuspected difficulty in synthesizing such peptide analogues, as illustrated by the synthesis of tripeptide derivatives containing two consecutive aza-amino acids. Herein, we report some general guidelines regarding the activation and the coupling of alkyl-hydrazides either mutually or with a natural amino acid, taking into account their nucleophilicity and the nature of their side chains.

A novel naphthylmethyleneimino-type photocleavable protecting group for primary amines

A novel naphthylmethyleneimino-type protecting group for aliphatic and aromatic primary amines including α-amino acids was devised and its introduction was accomplished in good to excellent yields. This type of protecting group was found to be cleanly removed photochemically to regenerate the primary amines in good to high yields, regardless of steric and electronic properties. Georg Thieme Verlag Stuttgart.

HIV protease inhibiting compounds

A compound of the formula is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.