16264-08-7

Basic information

• Product Name: 1-Acetyl-4-(4-nitrophenyl)piperazine
• Synonyms: 1-Acetyl-4-(4-nitrophenyl)piperazine;1-[4-(4-Nitrophenyl)piperazin-1-yl]ethan-1-one;1-(4-(4-Nitrophenyl)piperazin-1-yl)ethanone;1-Acetyl-4-(4-nitrophenyl)piperazine, 4-(4-Acetylpiperazin-1-yl)nitrobenzene;Ethanone,1-[4-(4-nitrophenyl)-1-piperazinyl]-
• CAS NO: 16264-08-7
• Molecular Formula: C₁₂H₁₅N₃O₃
• Molecular Weight: 249.27
• Mol File: 16264-08-7.mol
• Article Data: 22

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-Acetyl-4-(4-nitrophenyl)piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Acetyl-4-(4-nitrophenyl)piperazine(16264-08-7)
• EPA Substance Registry System: 1-Acetyl-4-(4-nitrophenyl)piperazine(16264-08-7)

Safety Data

• Hazardous Substances Data: 16264-08-7(Hazardous Substances Data)

Usage

General Description

1-Acetyl-4-(4-nitrophenyl)piperazine is a chemical compound that consists of a piperazine ring with an acetyl group and a 4-nitrophenyl group attached. It is commonly used as an intermediate in the synthesis of pharmaceutical compounds and has been studied for its potential pharmacological properties, including its role as a potential antipsychotic. It has also been investigated for its anti-inflammatory and analgesic effects. 1-Acetyl-4-(4-nitrophenyl)piperazine has the potential for both therapeutic and research applications due to its diverse pharmacological properties and structural versatility. However, further research is needed to fully understand its biological activities and potential medical uses.

Upstream product

• 6269-89-2 1-(4-Nitrophenyl)piperazine 
• 108-24-7 acetic anhydride 
• 13889-98-0 N-acetylpiperidine 
• 350-46-9 4-Fluoronitrobenzene 
• 1247549-57-0 2-(piperazin-1-yl)acetaldehyde 
• 75-36-5 acetyl chloride 
• 636-98-6 p-nitrobenzene iodide 
• 586-78-7 para-nitrophenyl bromide 
• 7087-68-5 N-ethyl-N,N-diisopropylamine 

Downstream Products

• 1314996-66-1 2-[4-(4-Acetylpiperazin-1-yl)phenylamino]-7-amino-8-ethyl-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide 
• 92394-00-8 1-acetyl-4-(4-aminophenyl)piperazine 

Relevant articles and documents

FUSED PYRIMIDINE PYRIDINONE COMPOUNDS AS JAK INHIBITORS

The disclosure provides compounds of formula (I), or a pharmaceutically-acceptable salt thereof, wherein the variables are defined in the specification, that are inhibitors of JAK kinases, particularly JAK3. The disclosure also provides pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat gastrointestinal inflammatory diseases.

“On Water” promoted N-arylation reactions using Cu (0)/myo-inositol catalytic system

Myo-inositol is originally applied as a cardiovascular medicine in clinic, which can be multi-ton manufactured via extraction from the byproducts in agricultural product processing such as defatted rice bran and corn-soaking water. Herein, the application of myo-inositol (MI) as a novel versatile tridentate O-donor ligand has been first described for promoting Cu-catalyzed amination reaction in aqueous medium.

2,4-dibasic miazines compound

The invention belongs to the field of medical chemistry, relates to a 2,4-dibasic miazines compound and specifically relates to a compound shown as formula (I) or a pharmaceutically acceptable salt thereof, a drug compound thereof and an application thereof in treating EGFR or/and ALK mediated diseases.