16273-84-0

Upstream product

• 2459-09-8 4-pyridinecarboxylic acid, methyl ester 
• 141-52-6 sodium ethanolate 
• 140-29-4 phenylacetonitrile 
• 1878-66-6 4-chlorophenylacetic Acid 
• 140-53-4 p-chlorobenzyl cyanide 
• 114443-86-6 [(Z)-2-(4-Chloro-phenyl)-1-pyridin-4-yl-vinyl]-phenyl-amine 
• 3360-72-3 (anilino-pyridin-4-yl-methyl)-phosphonic acid diphenyl ester 
• 872-85-5 pyridine-4-carbaldehyde 

Downstream Products

• 416852-64-7 C₃₀H₄₁ClN₄O₄ 
• 416852-65-8 C₃₀H₃₉ClN₄O₄ 
• 416849-76-8 C₂₆H₃₄ClN₅O₂ 
• 416849-77-9 C₂₉H₃₈ClN₅O₄ 
• 416852-63-6 C₁₃H₁₈ClNO 
• 114443-56-0 4-[2-(4-Chloro-phenyl)-acetyl]-1-methyl-pyridinium; bromide 

Relevant academic research and scientific papers

Design and synthesis of 4,5-diaryl/heteroarylthiophene-2-carboxylic acid derivatives and evaluation of their biological activities

Synthesis, characterization and biological activity of novel 4,5-diaryl/heteroaryl thiophene-2-carboxylic acid derivatives are described. Aryl/heteroaryl esters were converted to substituted thiophene esters via a Vilsmeier-Haack reaction, which were then hydrolyzed to 4,5-diaryl/heteroaryl thiophene-2-carboxylic acid derivatives 8a-h. All products were characterized by 1H NMR, 13C NMR, IR and MS. Antibacterial activity of the synthesized compounds against two Gram-positive and two Gram-negative bacteria, as well as their anticancer activity against PC-3 cell line (human prostate cancer cell lines) were evaluated.

Triazolopyrimidine heterocycles as cannabinoid receptor modulators

The present application describes compounds according to Formula I, pharmaceutical compositions comprising at least one compound according to Formula I and optionally one or more additional therapeutic agents and methods of treatment using the compounds a

An improved and practical procedure for the synthesis of substituted phenylacetylpyridines

A general procedure for the synthesis of substituted phenylacetylpyridines in excellent yields is described using a Horner-Emmons condensation between α-aminoalkylphosphonates of pyridinecarboxaldehydes and benzaldehydes with cesium carbonate at room temperature.

Equilibrium and Kinetic Acidities of Benzylic Ketones. Application of the Marcus Equation to the Deprotonation of Carbon Acids

Equilibrium constants and rates of ketone-enolate ion equilibration have been measured for the deprotonation of eight 3-(X-phenylacetyl)pyridines 1 (pKa 13.2 for X = H), ten 4-(X-phenylacetyl)pyridines 2 (pKa 12.2 for X = H), nine 1-