16275-33-5Relevant academic research and scientific papers
Fragment based lead discovery of small molecule inhibitors for the EPHA4 receptor tyrosine kinase
Van Linden, Oscar P.J.,Farenc, Carine,Zoutman, Willem H.,Hameetman, Liesbeth,Wijtmans, Maikel,Leurs, Rob,Tensen, Cornelis P.,Siegal, Gregg,De Esch, Iwan J.P.
supporting information; experimental part, p. 493 - 500 (2012/03/11)
The in silico identification, optimization and crystallographic characterization of a 6,7,8,9-tetrahydro-3H-pyrazolo[3,4-c]isoquinolin-1-amine scaffold as an inhibitor for the EPHA4 receptor tyrosine kinase is described. A database containing commercially
NOVEL LACTAM SYNTHESIS VIA ENOL LACTONE
Hamaoka, Shin-ichi,Kawaguchi, Mami,Mori, Miwako
, p. 167 - 170 (2007/10/02)
The lactams (11) and (13) were synthesized by the reaction of amine with the enol lactones (12), which were prepared from the enol triflates (5) using palladium catalyzed carbonylation.
