1627500-60-0Relevant articles and documents
5-BENZYLIDENE-4-OXAZOLIDINONES
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Page/Page column 36, (2018/03/25)
Provided herein are compounds that can exhibit activity as biofilm modulating agents (e.g., activity as biofilm inhibitors and/or activity as biofilm dispersal agents). The compounds can exhibit potent activity against Gram positive biofilms. The compound
A rapid synthesis of 4-oxazolidinones: Total synthesis of synoxazolidinones A and B
Shymanska, Nataliia V.,An, Il Hwan,Pierce, Joshua G.
supporting information, p. 5401 - 5404 (2014/06/09)
A five-step total synthesis of the marine natural product synoxazolidinone A was achieved through a diastereoselective imine acylation/cyclization cascade. Synoxazolidinone B and a series of analogues were also prepared to explore the potential of these 4-oxazolidinone natural products as antimicrobial agents. These studies confirmed the importance of the chlorine substituent for antimicrobial activity and revealed simplified dichloro derivatives that are equally potent against several bacterial strains. Synthetic synoxazolidinones: A five-step total synthesis of the marine natural product synoxazolidinone A was achieved through a diastereoselective imine acylation/cyclization cascade. Synoxazolidinone B and a series of analogues were also prepared to explore the potential of these 4-oxazolidinones as antimicrobial agents. The results revealed simplified dichloro derivatives that are equally potent against several bacterial strains.