162780-30-5

Basic information

• Product Name: (+)-ethyl (S)-2-N-benzylamino-4-phenylbutyrate
• Synonyms: (+)-ethyl (S)-2-N-benzylamino-4-phenylbutyrate
• CAS NO: 162780-30-5
• Molecular Weight: 297.397
• Mol File: 162780-30-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (+)-ethyl (S)-2-N-benzylamino-4-phenylbutyrate(CAS DataBase Reference)
• NIST Chemistry Reference: (+)-ethyl (S)-2-N-benzylamino-4-phenylbutyrate(162780-30-5)
• EPA Substance Registry System: (+)-ethyl (S)-2-N-benzylamino-4-phenylbutyrate(162780-30-5)

Safety Data

• Hazardous Substances Data: 162780-30-5(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 90891-21-7 L-(+)-α-amino-4-phenylbutyric acid ethyl ester hydrochloride 
• 244277-48-3 ethyl (R)-(-)-2-hydroxy-4-oxo-4-phenylbutanoate 
• 88330-79-4 ethyl-(Z)-2-hydroxy-4-oxo-4-phenyl-but-2-enoate 
• 90315-82-5 ethyl (R)-2-hydroxy-4-phenylbutyrate 

Downstream Products

• 1161828-76-7 N-benzyl-N-methyl-L-homophenylalanine ethyl ester 
• 46460-23-5 ethyl 2-amino-4-phenyl-(2S)-butyrate 

Relevant articles and documents

Ethyl 2,4-dioxo-4-phenylbutyrate: A versatile intermediate for the large-scale preparation of enantiomerically pure α-hydroxy and α-amino acid esters

Starting from ethyl 2,4-dioxo-4-phenylbutyrate, both enantiomers of six enantiomerically pure α-hydroxy and α-amino acid esters (homophenylalanine derivatives) were prepared on >100 g scale. The key step involves a Pt-cinchona catalyzed enantioselective hydrogenation followed by enrichment via crystallization. All derivatives are commercially available.