16279-88-2

Basic information

• Product Name: 4-(1H-1,2,3-Triazole-1-yl)aniline
• Synonyms: 1-(4-Aminophenyl)-1H-1,2,3-triazole;4-(1H-1,2,3-Triazole-1-yl)aniline;1-(4-AMINO-PHENYL)-1,2,3-TRIAZOLE;4-(1H-1,2,3-Triazol-1-yl)benzenamine;4-(1H-1,2,3-triazol-1-yl)aniline
• CAS NO: 16279-88-2
• Molecular Formula: C₈H₈N₄
• Molecular Weight: 160.18
• Mol File: 16279-88-2.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 362.1±44.0 °C(Predicted)
• Appearance: /
• Density: 1.32±0.1 g/cm3(Predicted)
• PKA: 3.44±0.10(Predicted)
• CAS DataBase Reference: 4-(1H-1,2,3-Triazole-1-yl)aniline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(1H-1,2,3-Triazole-1-yl)aniline(16279-88-2)
• EPA Substance Registry System: 4-(1H-1,2,3-Triazole-1-yl)aniline(16279-88-2)

Safety Data

• Hazardous Substances Data: 16279-88-2(Hazardous Substances Data)

Usage

General Description

4-(1H-1,2,3-Triazole-1-yl)aniline is a chemical compound that consists of a triazole ring and an aniline group. It is commonly used as a building block in medicinal chemistry for the synthesis of various pharmaceuticals and bioactive compounds. 4-(1H-1,2,3-Triazole-1-yl)aniline has been studied for its potential antifungal, antibacterial, and antitumor properties. Additionally, it has been investigated for its role in the development of new materials and as a ligand in coordination chemistry. The chemical structure of 4-(1H-1,2,3-Triazole-1-yl)aniline makes it a versatile and useful intermediate in the production of a wide range of organic compounds.

Upstream product

• 1204-91-7 1-(4-nitrophenyl)-1H-1,2,3-triazole 
• 288-36-8 1,2,3-triazole 
• 350-46-9 4-Fluoronitrobenzene 
• 106-40-1 4-bromo-aniline 
• 288-36-8 1 ,2,3-Triazole 
• 100-01-6 4-nitro-aniline 

Downstream Products

• 128864-34-6 1-(4-mercaptophenyl)-1,2,3-triazole 
• 128864-35-7 4-(1,2,3-triazol-1-yl)-phenyl disulfide 
• 482306-01-4 5-Chloro-N-(2-hydroxy-3-{[4-(1H-1,2,3-triazol-1-yl)phenyl]amino}propyl)-2-thiophenecarboxamide 
• 1201786-06-2 N-(4-(2-(4-(1H-1,2,3-triazol-1-yl)phenylamino)pyrimidin-4-yl)phenyl)methanesulfonamide 
• 1128095-94-2 N-(4-(1H-1,2,3-triazol-1-yl)phenyl)-4-(3-morpholinophenyl)-pyrimidin-2-amine 
• 217654-52-9 1-(2,2-diethoxyethyl)-1-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(1H-1,2,3-triazol-1-yl)phenyl]urea 
• 181870-02-0 1-(2,2-diethoxy-ethyl)-3-(4-[1,2,3]triazol-1-yl-phenyl)-urea 
• 181869-83-0 C₉H₁₀N₆O 
• 181870-08-6 1-[4-(1H-1,2,3-triazol-1-yl)phenyl]-2(1H,3H)-imidazolone 
• 181869-23-8 1-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(1H-1,2,3-triazol-1-yl)phenyl]-2-(1H,3H)-imidazolone 
• 181869-75-0 phenyl 4-(1H-1,2,3-triazol-1-yl)phenylcarbamate 
• 144-62-7 oxalic acid 

Relevant articles and documents

NOVEL COMPOUNDS

The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C-terminal hydrolase L1 (UCHL1). The invention further relates to the use of DUB inhibitors in the treatment of cancer and other indications. Compounds of the invention include compounds having the formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 to R8 are as defined herein.

HEPARAN SULFATE BIOSYNTHESIS INHIBITORS FOR THE TREATMENT OF DISEASES

Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or conditions in need of inhibition of heparan sulfate biosynthesis.

HIV PROTEASE INHIBITORS

Compounds of Formula I are disclosed: wherein A, R1, R2, R3, R4A, R4B, R5, R6 and R7 are defined herein. The compounds encompassed by Formula I include compounds which