1628-20-2

Upstream product

• 930-88-1 N-methylmaleimide 
• 1679-18-1 4-Chlorophenylboronic acid 
• 140-53-4 p-chlorobenzyl cyanide 
• 398130-11-5 3-(4-chloro-phenyl)-4-methylsulfanyl-pyrrole-2,5-dione 5-oxime 
• 398130-20-6 3-(4-chlorophenyl)-4-(methylthio)-1H-pyrrole-2,5-dione 
• 1028257-13-7 (E)-2-(4-Chloro-phenyl)-3-methylsulfanyl-4-nitro-but-3-enenitrile 
• 398130-30-8 3-(4-chloro-phenyl)-1-methyl-4-methylsulfanyl-pyrrole-2,5-dione 
• 58755-91-2 2-(4-chlorophenyl)succinic acid 
• 74-89-5 methylamine 

Relevant academic research and scientific papers

Pd(II)/bipyridine catalyzed conjugate addition of arylboronic acids to α,β-unsaturated amides

The Pd(II)/bipyridine-catalyzed conjugate addition of arylboronic acid to α,β-unsaturated amides was developed and optimized, and the reaction was proceeded smoothly in air. A series of arylboronic acid and α,β-unsaturated amide substrates were surveyed, and modest to excellent yields were given.

Synthesis of 3-methylthio-4-aryl-3-pyrroline-2,5-diones and 3-arylpyrolidine-2,5-diones by reaction of nitroketene dithioacetal with arylacetonitriles

The reaction of nitroketene dithioacetal (1a), i.e., 2,2-bis(methylthio)-1-nitroethylene, with arylacetonitriles (2a-I) in the presence of the base like sodium hydroxide gave 4-nitrobut-2-enenitriles (3a-I) which were convened into 5-hydroxyimino-4-methylthio-3-phenyl-3-pyrrolin-2-ones (4a-i) under refluxing in methanol. Title compounds (5a-i) were readily obtained by the treatment of 4a-i with hydrochloric acid and were finally led to N-methylated products (6a-I) with methyl iodide. The reduction of maleimides (4 - 6) with zinc dust in acetic acid afforded the corresponding 3-arylpyrrolidine-2,5-diones (7a-i) that can be convened to pharmacologycally active compounds like mesembrines.