2-(p-Chlorophenyl)-N-methylsuccinimide

Base Information

• Chemical Name: 2-(p-Chlorophenyl)-N-methylsuccinimide
• CAS No.: 1628-20-2
• Molecular Formula: C11H10 Cl N O2
• Molecular Weight: 223.659
• NSC Number: 404581
• Nikkaji Number: J1.448.086B
• Mol file: 1628-20-2.mol

Synonyms:1628-20-2;2-(p-Chlorophenyl)-N-methylsuccinimide;NSC 404581;BRN 0175922;Succinimide, 2-(p-chlorophenyl)-N-methyl-;NSC404581;2,5-Pyrrolidinedione, 3-(4-chlorophenyl)-1-methyl-;NSC-404581

Chemical Property of 2-(p-Chlorophenyl)-N-methylsuccinimide

Chemical Property:

• Vapor Pressure: 6.01E-06mmHg at 25°C
• Boiling Point: 379.1°Cat760mmHg
• Flash Point: 183.1°C
• Density: 1.324g/cm³
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 223.0400063
• Heavy Atom Count: 15
• Complexity: 284

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1C(=O)CC(C1=O)C2=CC=C(C=C2)Cl

Technology Process of 2-(p-Chlorophenyl)-N-methylsuccinimide

There total 8 articles about 2-(p-Chlorophenyl)-N-methylsuccinimide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

3-(4-chloro-phenyl)-1-methyl-4-methylsulfanyl-pyrrole-2,5-dione (398130-30-8) → N-methyl-2-p-chlorophenylsuccinimide (1628-20-2)

Guidance literature:

With acetic acid; zinc; for 1h; Heating;

DOI:10.3987/COM-01-9336

Reference yield: 74.0%

N-methylmaleimide (930-88-1) + 4-Chlorophenylboronic acid (1679-18-1) → N-methyl-2-p-chlorophenylsuccinimide (1628-20-2)

Guidance literature:

With 4,4'-bipyridine; palladium diacetate; acetic acid; In tetrahydrofuran; water; at 80 ℃; for 24h; Schlenk technique;

DOI:10.1016/j.tetlet.2016.05.022

Reference yield:

2-(4-chlorophenyl)succinic acid (58755-91-2) + methylamine (74-89-5) → N-methyl-2-p-chlorophenylsuccinimide (1628-20-2)

Guidance literature:

With water; at 200 ℃;

DOI:10.1021/ja01120a044

upstream raw materials:

2-(4-chlorophenyl)succinic acid

methylamine

3-(4-chloro-phenyl)-1-methyl-4-methylsulfanyl-pyrrole-2,5-dione

(E)-2-(4-Chloro-phenyl)-3-methylsulfanyl-4-nitro-but-3-enenitrile