1628077-36-0

Upstream product

• 1345447-25-7 4-chloro-6-iodo-3-nitroquinoline 
• 115279-57-7 2-(4-aminophenyl)-2-methylpropionitrile 
• 71825-51-9 4-(2-cyanoprop-2-yl)-1-nitrobenzene 
• 1628078-09-0 2-(4-((6-iodo-3-nitroquinolin-4-yl)amino)phenyl)-2-methylpropanenitrile 
• 1345447-21-3 5-iodo-2-((2-nitrovinyl)amino)benzoic acid 
• 1203578-70-4 6-iodo-3-nitroquinolin-4-ol 

Downstream Products

• 1201646-92-5 2-(4-((3'-amino[3,6'-biquinolin]-4'-yl)amino)phenyl)-2-methyl propanenitrile 
• 1628077-34-8 2-(4-(8-iodo-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile 
• 1610680-66-4 2-(4-(8-amino-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile 
• 1610680-65-3 2-methyl-2-(4-(3-methyl-8-morpholino-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)propanenitrile 
• 1610680-64-2 2-methyl-2-(4-(3-methyl-8-(4-methylpiperazin-1-yl)-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)propanenitrile 
• 1610680-72-2 2-(4-(8-(benzo[b]thiophen-2-yl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile 
• 1370615-16-9 2-methyl-2-(4-(3-methyl-8-(1-methyl-1H-pyrazol-4-yl)-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)propanenitrile 
• 1610680-71-1 2-methyl-2-(4-(3-methyl-2-oxo-8-(6-(trifluoromethyl)pyridin-3-yl)-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)propanenitrile 
• 1610680-70-0 2-methyl-2-(4-(3-methyl-2-oxo-8-phenyl-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)propanenitrile 
• 1610680-69-7 2-methyl-2-(4-(3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)propanenitrile 
• 1610680-68-6 2-(4-(3,8-dimethyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile 
• 1610680-67-5 N-(1-(4-(2-cyanopropan-2-yl)phenyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-8-yl)acetamide 
• 1610680-63-1 2-(4-(8-iodo-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile 

Relevant academic research and scientific papers

Establishment of a structure-activity relationship of 1 H-imidazo[4,5-c]quinoline-based kinase inhibitor NVP-BEZ235 as a lead for African sleeping sickness

Compound NVP-BEZ235 (1) is a potent inhibitor of human phospoinositide-3- kinases and mammalian target of rapamycin (mTOR) that also showed high inhibitory potency against Trypanosoma brucei cultures. With an eye toward using 1 as a starting point for ant