1628535-46-5Relevant academic research and scientific papers
Stereoselective total syntheses of paecilomycins e and F through a protecting group directed diastereoselective intermolecular Nozaki-Hiyama-Kishi (NHK) reaction
Mohapatra, Debendra K.,Reddy, D. Sai,Mallampudi, N. Arjunreddy,Yadav, Jhillu S.
, p. 5023 - 5032 (2014)
An efficient and concise approach to the total syntheses of paecilomycins E (1) and F (2) is described. A protecting group directed intermolecular diastereoselective Nozaki-Hiyama-Kishi (NHK) reaction, a Julia-Kocienski olefination, a Sharpless asymmetric dihydroxylation, and De Brabander's lactonization protocol are used as the key steps.
Asymmetric total synthesis of filamentous fungi related resorcylic acid lactones 7-epi-zeaenol and zeaenol
Doda, Sai Reddy,Raghavendar, Avula,Haridasyam, Sharath Babu,Putta, Chandra Shekar,Rao, Bhattu Kanakadurga,Kadari, Sudhakar
, p. 78 - 84 (2019/06/06)
An efficient, short and, a convenient asymmetric total synthesis of filamentous fungi related resorcylic acid lactones 7-epi-zeaenol (2) and zeaenol (1) have been achieved in 7 and 9 linear steps with the high overall yield of 32% and 21% respectively, from the known intermediate 13. Mitsunobu inversion, De Brabander's protocol for macrolactonisation, Heck cross-coupling, diastereoselective alkyne aldehyde coupling and Ohira-Bestmann alkynylation are the key reactions.
