924647-38-1

Basic information

• Product Name: 1-(2,2-difluoroethoxy)-2-(propylsulphanyl)-3-(trifluoromethyl)benzene
• Synonyms: 1-(2,2-difluoroethoxy)-2-(propylsulphanyl)-3-(trifluoromethyl)benzene
• CAS NO: 924647-38-1
• Molecular Weight: 300.293
• Mol File: 924647-38-1.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 1-(2,2-difluoroethoxy)-2-(propylsulphanyl)-3-(trifluoromethyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,2-difluoroethoxy)-2-(propylsulphanyl)-3-(trifluoromethyl)benzene(924647-38-1)
• EPA Substance Registry System: 1-(2,2-difluoroethoxy)-2-(propylsulphanyl)-3-(trifluoromethyl)benzene(924647-38-1)

Safety Data

• Hazardous Substances Data: 924647-38-1(Hazardous Substances Data)

Upstream product

• 359-13-7 difluoroethanol 
• 401-80-9 3-fluoro-trifluoromethylbenzene 
• 39974-35-1 2-chloro-1-nitro-3-(trifluoromethyl)benzene 
• 493038-92-9 1,2-dibromo-3-trifluoromethylbenzene 
• 367-67-9 2-bromo-5-nitro-benzotrifluoride 
• 420-43-9 1-bromo-1,1-difluoroethane 
• 896732-43-7 2-(3-(trifluoromethyl)phenoxy)tetrahydro-2H-pyran 
• 163035-65-2 methanesulfonic acid 2,2-difluoroethyl ester 

Downstream Products

• 865352-01-8 2-(2',2'-difluoroethoxy)-6-trifluoromethylbenzene-1-sulfonyl chloride 

Relevant articles and documents

Synthesis method of 2-(2, 2-difluoroethyoxyl)-6-trifluoromethyl benzenesulfonyl chloride

The invention discloses a synthesis method of 2-(2, 2-difluoroethyoxyl)-6-trifluoromethyl benzenesulfonyl chloride. The preparation method comprises the following steps: dissolving 2-trifluoromethyl-4-nitro-bromobenzene in sulfuric acid, adding a halogenating reagent, and reacting at 50-100 DEG C for 1-8 hours; dissolving the obtained 2-bromo-3-trifluoromethyl-5-nitro-benzene halide in a solvent, and performing reduction in a reduction system; carrying out diazotization on the obtained 3-halo-4-bromo-5-trifluoromethyl-aniline, and then carrying out decomposition on the obtained 3-halo-4-bromo-5-trifluoromethyl-aniline; carrying out Grignard reaction on the obtained 2-bromo-3-trifluoromethyl-benzene halide, and then reacting with dialkyl disulfide; carrying out etherification reaction on the obtained 2-alkylthio-3-trifluorotoluene-benzene halide and 2, 2-difluoroethanol in an organic solvent under the action of an alkali; and reacting the obtained 2-(2, 2-difluoroethoxy)-6-trifluoromethyl-phenylalkyl sulfide with chlorine gas at 10-60 DEG C for 1-5 hours. The method is short in route, mild in condition, high in yield and suitable for industrial production.

Convenient Synthesis of 2-(2,2-Difluoroethoxy)-6-(trifluoromethyl)-benzenesulfonyl Chloride, A Key Building Block of Penoxsulam

A convenient and efficient three-step synthesis of 2-(2,2-difluoroethoxy)-6-(trifluoromethyl)benzenesulfonyl chloride, the key building block of penoxsulam, is described. The main features of the synthesis include a regioselective lithiation and subsequent electrophilic substitution starting from commercially available 3-bromobenzotrifluoride to provide (2-bromo-6-(trifluoromethyl)phenyl)(propyl)sulfane, then a copper-catalyzed C-O coupling to introduce the difluoroethoxy moiety and chloroxidation conditions to give the desired sulfonyl chloride.

2 - phenoxy four hydrogens fu ([...]) five fluorine sulphur grass amine[...] derivatives and their application in the synthesis of

The invention discloses 2-phenoxyl tetrahydrofuran (tetrahydropyrane) derivatives and the application thereof in synthesis of penoxsulam, and belongs to the field of pesticide synthesis. A new intermediate of a penoxsulam pesticide is synthesized by the derivatives of the design of the invention. A high-toxicity raw material is not required to be used in the preparation of the intermediate; a product is convenient to purify and high in yield; a synthesizing process is environment-friendly; the synthesis cost is low. The penoxsulam pesticide can be prepared conveniently by utilizing the intermediate; the intermediate has a good application prospect. The series of derivatives are easy and convenient to synthesize; compared with the reported penoxsulam intermediate, a low-boiling-point raw material with high toxicity, namely, chloromethyl methyl ether, is not required to be used in the synthesizing process; the safety of the synthesizing process is improved; the derivatives are favorable to industrialized production and application.