(R)-1-((R)-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)(4-methoxyphenyl)methoxy)-2-phenylpropan-2-ol

Base Information

Chemical Name:(R)-1-((R)-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)(4-methoxyphenyl)methoxy)-2-phenylpropan-2-ol
CAS No.:1632157-22-2
Molecular Formula:C₂₂H₂₈O₅
Molecular Weight:372.461
Hs Code.:

Synonyms:(R)-1-((R)-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)(4-methoxyphenyl)methoxy)-2-phenylpropan-2-ol

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Chemical Property of (R)-1-((R)-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)(4-methoxyphenyl)methoxy)-2-phenylpropan-2-ol

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Technology Process of (R)-1-((R)-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)(4-methoxyphenyl)methoxy)-2-phenylpropan-2-ol

There total 10 articles about (R)-1-((R)-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)(4-methoxyphenyl)methoxy)-2-phenylpropan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1632157-52-8
1-((R)-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)(4-methoxyphenyl)methoxy)propan-2-one

: 1632157-22-2
(R)-1-((R)-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)(4-methoxyphenyl)methoxy)-2-phenylpropan-2-ol

Guidance literature:: With magnesium bromide ethyl etherate; In tetrahydrofuran; dichloromethane; at -78 ℃; for 2h; diastereoselective reaction;
DOI:10.1055/s-0033-1340163

Reference yield:

: 1022915-06-5
2-((R)-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)(4-methoxyphenyl)methoxy)-1-phenylethanone

: 676-58-4
methylmagnesium chloride

: 1632157-22-2
(R)-1-((R)-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)(4-methoxyphenyl)methoxy)-2-phenylpropan-2-ol

: 1632157-36-8
C₂₂H₂₈O₅

Guidance literature:: With magnesium bromide ethyl etherate; In dichloromethane; at -78 ℃; for 2h; Overall yield = 81 %; diastereoselective reaction;
DOI:10.1055/s-0033-1340163

Reference yield:

: 102389-96-8
(2R,3R)-3-hydroxy-1,2-O-isopropylidene-3-p-methoxyphenyl-1,2-propanediol

: 1632157-22-2
(R)-1-((R)-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)(4-methoxyphenyl)methoxy)-2-phenylpropan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 °C

2: ozone / methanol; dichloromethane / 2 h / -78 - 20 °C

3: magnesium bromide ethyl etherate / tetrahydrofuran; dichloromethane / 2 h / -78 °C

With sodium hydride; ozone; magnesium bromide ethyl etherate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1055/s-0033-1340163