163432-24-4

Upstream product

• 118740-38-8 chloro(α,α-dimethylbenzyl)dimethylsilane 
• 167172-38-5 3-Hydroxy-2,2-dimethyl-cyclooctanone 
• 55277-52-6 2,2-dimethylcyclooctane-1,3-dione 

Relevant academic research and scientific papers

Construction of AB-ring system of taxane framework by A-ring annulation strategy: Synthesis of 1-hydroxy-8,11,11-trimethylbicyclo[5.3.1]undec-7-en- 9-one by way of intramolecular aldol cyclization to form the C1-C10 bond

Construction of the AB-ring system of the taxane framework via an A- ring annulation strategy was demonstrated by base-mediated intramolecular aldol reaction of (Z)-2,2-dimethyl-3-(1-methyl-2- oxopropylidene)cyclooctanone, affording the title compound, 1-

Synthesis of AB Ring Model System of Taxol via Allylation of 8-Membered Ring Compound and Intramolecular Aldol Condensation

1-t-Butyldimethylsiloxy-8,11,11-trimethylbicycloundec-7-en-9-one (2) has been synthesized via intramolecular aldol condensation of the precursor 3 by combined use of lithium diisopropylamide (LDA) and CeCl3. the dicarbonyl compound 3 was prepared b