Synthesis of AB Ring Model System of Taxol via Allylation of 8-Membered Ring Compound and Intramolecular Aldol Condensation

Article abstract of DOI:10.1246/cl.1995.229

1-t-Butyldimethylsiloxy-8,11,11-trimethylbicyclo<5.3.1>undec-7-en-9-one (2) has been synthesized via intramolecular aldol condensation of the precursor 3 by combined use of lithium diisopropylamide (LDA) and CeCl3. the dicarbonyl compound 3 was prepared b