Construction of AB-ring system of taxane framework by A-ring annulation strategy: Synthesis of 1-hydroxy-8,11,11-trimethylbicyclo[5.3.1]undec-7-en- 9-one by way of intramolecular aldol cyclization to form the C1-C10 bond

DOI: 10.1248/cpb.45.1898

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1898 - 1905 (1997)

Update date:2022-07-29

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Authors:

Yamada, Koji

Iwadare, Hayato

Mukaiyama, Teruaki

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Article abstract of DOI:10.1248/cpb.45.1898

Construction of the AB-ring system of the taxane framework via an A- ring annulation strategy was demonstrated by base-mediated intramolecular aldol reaction of (Z)-2,2-dimethyl-3-(1-methyl-2- oxopropylidene)cyclooctanone, affording the title compound, 1-

Full text of DOI:10.1248/cpb.45.1898

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