29368-94-3Relevant academic research and scientific papers
Imidazole hydrochloride promoted synthesis of 3,5-disubstituted-1,2,4-oxadiazoles
Wang, Xuetong,Wang, Yin,Liu, Xiaoling,He, Tingshu,Li, Lingli,Wu, Huili,Zhou, Shangjun,Li, Dan,Liao, Siwei,Xu, Ping,Huang, Xing,Yuan, Jianyong
, (2021/10/14)
Imidazole hydrochloride as an additive promotes the reaction of amidoximes and DMA derivatives to generated 3,5-disubstituted-1,2,4-oxadiazoles in low to excellent yields without the use of coupling reagents, oxidants, strong acids or bases and other additives.
Improved and expanded one-pot, two-component Boulton-Katritzky syntheses of N–N bond containing bicyclic heterocycles
Knouse, Kyle W.,Ator, Laura E.,Beausoleil, Lauren E.,Hauseman, Zachary J.,Casaubon, Rebecca L.,Ott, Gregory R.
, p. 202 - 205 (2016/12/28)
Improved and expanded one-pot, two-component syntheses of bicyclic heterocycles containing a 3-N-acyl-3-amino-1,2-pyrazole motif from N'-hydroxy-carboxyamidines and acylbenzotriazoles have been developed. Importantly, this sequence obviates the need for h
Synthetic studies toward 3-(acylamino)-1 H-indazoles and development of a one-pot, microwave-assisted, oxadiazole condensation/Boulton-Katritzky rearrangement
Ott, Gregory R.,Anzalone, Andrew V.
, p. 3018 - 3022 (2012/01/05)
Studies on the Boulton-Katritzky rearrangement of 3-(2-aminoaryl)-1,2,4- oxadiazoles have led to the identification of additional electronic factors that govern the rearrangement as well as a competitive thermal rearrangement pathway for select substrates
2-(anilinomethyl)imidazolines as alpha1A adrenergic receptor agonists: 2'-heteroaryl and 2'-oxime ether series.
Navas 3rd., Frank,Bishop, Michael J,Garrison, Deanna T,Hodson, Stephen J,Speake, Jason D,Bigham, Eric C,Drewry, David H,Saussy, David L,Liacos, James H,Irving, Paul E,Gobel, M Jeffrey
, p. 575 - 579 (2007/10/03)
A series of 2'-heteroaryl and 2'-oxime anilinomethylimidazolines was prepared and evaluated in in vitro functional assays for cloned human alpha1A, alpha1B, and alpha1D receptor subtypes. Potent and selective alpha1A agonists have been identified in these series.
pH Dependent Alternative Ring Closure of Monoacyl 2-Aminobenzamide Oximes. A New 2-Aminobenzimidazole Synthesis
Korbonits, Dezso,Kolonits, Pal
, p. 1652 - 1665 (2007/10/02)
N-Acyl and O-acyl derivatives of 2-aminobenzamide oxime (1) are versatile synthons to prepare different types of heterocycles by intramolecular condensations in which the two nitrogen atoms of the amide oxime moiety, the aromatic amino nitrogen and C-1 of
Ring Transformation of 3-(2-Aminoaryl)-1,2,4-oxadiazoles into 3-Acylaminoindazoles; Extension of the Boulton-Katritzky Scheme
Korbonits, Dezsoe,Kanzel-Szvoboda, Ida,Horvath, Karoly
, p. 759 - 766 (2007/10/02)
The ring transformation of 3-(2-aminoethyl)-1,2,4-oxadiazoles (1) into acylaminopyrazolines (2) reported earlier has been extended to 5-substituted 3-(2-aminoaryl)-1,2,4-oxadiazoles (3), (5), (7), and (9).Depending on the reaction conditions and the subst
