16358-44-4

Upstream product

• 103-90-2 4-acetaminophenol 
• 76-05-1 trifluoroacetic acid 
• 100-97-0 hexamethylenetetramine 
• 24590-01-0 acetyloxy(2-acetyloxy-5-nitrophenyl)methyl acetate 
• 24590-02-1 5-Acetamido-2-acetoxy-benzaldiacetat 
• 50-00-0 formaldehyd 

Downstream Products

• 1338533-34-8 methyl 2-(2-formyl-4-acetamidophenoxy)hexanoate 
• 1278585-63-9 2-n-butyl-3-(4-methoxybenzoyl)-5-acetamidobenzofuran 
• 1278585-66-2 2-n-butyl-3-(4-hydroxybenzoyl)-5-acetamidobenzofuran 
• 1278585-69-5 N-(2-butyl-3-(4-(3-(dibutylamino)propoxy)benzoyl)benzofuran-5-yl)acetamide 
• 1338533-35-9 2-(2-formyl-4-acetamidophenoxy)hexanoic acid 
• 526196-92-9 (2-n-butyl-benzofuran-5-yl)-acetamide 

Relevant academic research and scientific papers

NITROALKENE NON STEROIDAL ANTI-INFLAMMATORY DRUGS (NA-NSAIDS) AND METHODS OF TREATING INFLAMMATION RELATED CONDITIONS

Nitroalkene non-steroidal anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of treating inflammation related conditions.

NITROALKENE NON STEROIDAL ANTI-INFLAMMATORY DRUGS (NA-NSAIDS) AND METHODS OF TREATING INFLAMMATION RELATED CONDITIONS

Nitroalkene non-steroidal anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of treating inflammation related conditions.

MgBr2 supported on Fe3O4@SiO2?~?urea nanoparticle: An efficient catalyst for ortho-formylation of phenols and oxidation of benzylic alcohols

Urea was successfully immobilized on the surface of chloropropyl-modified Fe3O4@SiO2 core–shell magnetic nanoparticles, then supported by MgBr2 and acts as a unique catalyst for oxidation of benzylic alcohols to aldehydes and ketones, and ortho-formylation of phenols to salicylaldehydes. The prepared catalyst was characterized by FT-IR, transmission electron microscopy, scanning electron microscopy, X-ray powder diffraction, dispersive X-ray spectroscopy, CHN and TGA. It was found that Fe3O4@SiO2?~?urea/MgBr2 showed higher catalytic activity than homogenous MgBr2, and could be reused several times without significant loss of activity.

PROCESS FOR PREPARING AMINOBENZOFURAN DERIVATIVES

This disclosure relates to a process for preparing 5-aminobenzofuran derivatives of general formula (I): in which R1 and R2 are as defined in the description, by treating a 5-N-alkylamidobenzofuran derivative of general formula (II): in which R1, R2, and R3 are as defined in the description, with a strong acid, so as to form an acid addition salt of the compound of formula (I), which salt is itself treated, if necessary, with a basic agent so as to form this compound of formula (I) in free base form.

Para-hydroxyalkylation of hydroxylated aromatic compounds

Hydroxylated aromatic compounds devoid of substituents in the para-position to the hydroxyl group thereof are para-hydroxyalkylated, e.g., into optionally substituted p-hydroxymandelic acid compounds, more particularly p-hydroxymandelic acid and 3-methoxy-p-hydroxymandelic acid, by condensing same with an organic carbonyl compound in the presence of a quaternary ammonium hydroxide.

Selective Reactions between Phenols and Formaldehyde. A Novel Route to Salicylaldehydes

Treatment of phenols (1) with 2 mol equiv. of paraformaldehyde in aprotic and poorly electron-donating solvents in the presence of selected metal halides coupled with suitable bases produces salicylaldehydes (3) in high yields.The route is highly selective for ortho-formylation and also specific towards monoformylation.The crucial role of added bases is emphasized.