1278585-69-5

Basic information

• Product Name: N-(2-butyl-3-(4-(3-(dibutylamino)propoxy)benzoyl)benzofuran-5-yl)acetamide
• Synonyms: N-(2-butyl-3-(4-(3-(dibutylamino)propoxy)benzoyl)benzofuran-5-yl)acetamide
• CAS NO: 1278585-69-5
• Molecular Weight: 520.712
• Mol File: 1278585-69-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: N-(2-butyl-3-(4-(3-(dibutylamino)propoxy)benzoyl)benzofuran-5-yl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-butyl-3-(4-(3-(dibutylamino)propoxy)benzoyl)benzofuran-5-yl)acetamide(1278585-69-5)
• EPA Substance Registry System: N-(2-butyl-3-(4-(3-(dibutylamino)propoxy)benzoyl)benzofuran-5-yl)acetamide(1278585-69-5)

Safety Data

• Hazardous Substances Data: 1278585-69-5(Hazardous Substances Data)

Upstream product

• 1278585-63-9 2-n-butyl-3-(4-methoxybenzoyl)-5-acetamidobenzofuran 
• 100-07-2 4-methoxy-benzoyl chloride 
• 1278585-66-2 2-n-butyl-3-(4-hydroxybenzoyl)-5-acetamidobenzofuran 
• 111-92-2 dibutylamine 
• 65136-48-3 4-(3-chloropropoxy)benzoic acid chloride 
• 772-33-8 Koshlands reagent I 
• 133238-87-6 2-(n-butyl)-5-nitrobenzofuran 
• 141645-23-0 (2-butyl-5-nitrobenzofuran-3-yl)(4-(3-(dibutylamino)propoxy)phenyl)methanone 
• 141645-16-1 2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran 
• 638-29-9 n-valeryl chloride 
• 141627-42-1 (2-butyl-5-nitrobenzofuran-3-yl)(4-methoxyphenyl)methanone 
• 16358-44-4 2-hydroxy-5-acetamidobenzaldehyde 
• 526196-92-9 (2-n-butyl-benzofuran-5-yl)-acetamide 
• 1338533-35-9 2-(2-formyl-4-acetamidophenoxy)hexanoic acid 

Downstream Products

• 1354567-98-8 2-n-butyl-3-{4-[3-(di-n-butylamino)propoxy]benzoyl}-5-aminobenzofuran hydrochloride 
• 500791-70-8 5-amino-2-n-butyl-3-[4-(3-di-n-butylamino propoxy)benzoyl]benzofuran bisoxalate 
• 141644-91-9 (5-amino-2-butyl-benzofuran-3-yl)-[4-(3-dibutylamino-propoxy)-phenyl]-methanone 

Relevant articles and documents

Discovery of dronedarone and its analogues as NLRP3 inflammasome inhibitors with potent anti-inflammation activity

Inhibiting NLRP3 inflammasome activation is a prospective therapeutic strategy for uncontrolled inflammatory diseases. It is the first time that dronedarone, a multiply ion channel blocker, was identified as a NLRP3-inflammasome inhibitor with an IC50 value of 6.84 μM against IL-1β release. A series of novel 5-amide benzofuran derivatives were designed and synthesized as NLRP3-inflammasome inhibitors. Compound 8c showed slightly increased activity (IC50 = 3.85 μM) against IL-1β release. Notably, treatment with 8c could significantly inhibit NLRP3-mediated IL-1β release and ameliorate peritoneal inflammation in a mouse model of sepsis. Collectively, 8c is a promising lead compound for further chemical development as a NLRP3 inhibitor with anti-inflammation effects.

2-butyl-3 - (4-substituted propoxy benzoyl) - 5-substituted aminobenzofuran and its application

The invention discloses 2-n-butyl-3-(4-subsitituted propylbenzoyl)-5-substituted amino benzofuran and application thereof. The 2-n-butyl-3-(4-subsitituted propylbenzoyl)-5-substituted amino benzofuran can be used for preparing dronedarone and pharmaceutic

PROCESS FOR PREPARING AMINOBENZOFURAN DERIVATIVES

This disclosure relates to a process for preparing 5-aminobenzofuran derivatives of general formula (I): in which R1 and R2 are as defined in the description, by treating a 5-N-alkylamidobenzofuran derivative of general formula (II): in which R1, R2, and R3 are as defined in the description, with a strong acid, so as to form an acid addition salt of the compound of formula (I), which salt is itself treated, if necessary, with a basic agent so as to form this compound of formula (I) in free base form.