163618-93-7

Upstream product

• 67-56-1 methanol 
• 163618-97-1 2-hydroxy-4-isopropoxybenzoic acid 
• 35212-22-7 Ipriflavone 
• 3669-41-8 1-(2,4-dihydroxyphenyl)-2-phenylethanone 
• 945745-54-0 methyl 2,4-diisopropyl benzoate 
• 945745-53-9 methyl 2-benzyloxy-4-isopropyl benzoate 
• 1165713-06-3 methyl 4-isopropoxy-2-(4-methoxy-benzyloxy)benzoate 
• 1165713-09-6 methyl 4-isopropoxy-2-methoxymethyloxybenzoate 
• 2150-47-2 methyl 2,4-dihydroxybenzoate 
• 75-26-3 isopropyl bromide 
• 75-30-9 2-iodo-propane 
• 50561-04-1 1-(2-hydroxy-4-isopropoxyphenyl)-2-phenyl-1-ethanone 
• 89-86-1 4-hydroxysalicylic acid 

Downstream Products

• 945745-53-9 methyl 2-benzyloxy-4-isopropyl benzoate 
• 1165713-09-6 methyl 4-isopropoxy-2-methoxymethyloxybenzoate 
• 1165713-06-3 methyl 4-isopropoxy-2-(4-methoxy-benzyloxy)benzoate 
• 365526-27-8 methyl 4-isopropoxy-2-methoxybenzoate 

Relevant academic research and scientific papers

Factors affecting orthogonality in the deprotection of 2,4-di-protected aromatic ethers employing solid-supported acids

Selective deprotection of aromatic ethers bearing two protecting groups on the same aromatic ring by solid-supported acids (Amberlyst-15 and PTS-Si) was systematically investigated. ortho-Directing protonation by the carbonyl group as well as carbocation stability and quenching are the important determining factors for the orthogonal deprotection process. Stablilized carbocations (e.g., those from the MOM and PMB groups) could be removed with high selectivity.

Solid-supported acids as mild and versatile reagents for the deprotection of aromatic ethers

Equation Presented p-Toluene sulfonic acid (p-TsOH) immobilized either on polystyrene (PS) or silica (Si) was found to be effective in cleaving aromatic ethers containing isopropyl, tert-butyl, allyl, and benzyl groups, as well as mono-, di-, and trimethoxylated benzyl groups, in moderate to excellent yields (54-95%). These protecting groups could be selectively deprotected when they were simultaneously present on the same or different aromatic rings in a substrate.

Phosphonic acid biaryl derivatives as inhibitors of protein tyrosine phosphatase 1B (PTP-1B)

The invention encompasses the novel class of compounds represented by formula I which are inhibitors of the PTP-1B enzyme. The invention also encompasses pharmaceutical compositions and methods of treating or preventing PTP-1B mediated diseases, including diabetes, obesity, and diabetes-related conditions.

Stability and chemical reactivity of 7-isopropoxyisoflavone (ipriflavone)

The stability (hydrolysis and oxidation) of ipriflavone (7-isopropoxyisoflavone, 1) was studied under basic and acidic conditions in different solvents; the effects of irradiation were investigated in methanol. Identification of the isolated products enabled suggestions to be made concerning the mechanisms of decomposition.

N-(3-pyrrolidinyl) benzamide derivative

N-(3-Pyrrodinyl)benzamide derivatives represented by the following general formula (I) which have potent and selective antagonism against dopamine D3 and/or D4 receptor and are useful as a psychotropic, a schizophrenia-treating agent and the like, or a pharmaceutically acceptable salt thereof or a pharmaceutical preparation thereof. STR1