16375-92-1

Basic information

• Product Name: N-[4-(1-Hydroxyethyl)phenyl]acetamide
• Synonyms: 4'-(1-Hydroxyethyl)acetanilide;N-[4-(1-Hydroxyethyl)phenyl]acetamide;4-(+/-)-±-hydroxyethylphenylacetamide
• CAS NO: 16375-92-1
• Molecular Formula: C₁₀H₁₃NO₂
• Molecular Weight: 179.22
• Mol File: 16375-92-1.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-[4-(1-Hydroxyethyl)phenyl]acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[4-(1-Hydroxyethyl)phenyl]acetamide(16375-92-1)
• EPA Substance Registry System: N-[4-(1-Hydroxyethyl)phenyl]acetamide(16375-92-1)

Safety Data

• Hazardous Substances Data: 16375-92-1(Hazardous Substances Data)

Upstream product

• 3663-34-1 N-(4-ethylphenyl)acetamide 
• 100-19-6 (4-nitrophenyl)ethanone 
• 93453-80-6 1-(4-aminophenyl)ethanol 
• 108-24-7 acetic anhydride 
• 2719-21-3 4-(N-acetylamino)acetophenone 

Downstream Products

• 122-80-5 N-acetyl-p-phenylenediamine 
• 1260236-30-3 N-(1-(4-acetamidophenyl)vinyl)acetamide 
• 120342-68-9 methyl N-(4-(1-azidoethyl)phenyl)acetamide 
• 2719-21-3 4-(N-acetylamino)acetophenone 
• 351-83-7 4'-fluoroacetanilide 

Relevant articles and documents

Estimation of the rates of available fraction for some 4-substituted acetophenone derivatives in the rat: Reversible drug-metabolite pharmacokinetics

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Selective Carbon-Carbon Bond Amination with Redox-Active Aminating Reagents: A Direct Approach to Anilines?

Amines are among the most fundamental motifs in chemical synthesis, and the introduction of amine building blocks via selective C—C bond cleavage allows the construction of nitrogen compounds from simple hydrocarbons through direct skeleton modification. Herein, we report a novel method for the preparation of anilines from alkylarenes via Schmidt-type rearrangement using redox-active amination reagents, which are easily prepared from hydroxylamine. Primary amines and secondary amines were prepared from corresponding alkylarenes or benzyl alcohols under mild conditions. Good compatibility and valuable applications of the transformation were also displayed.

A unified photoredox-catalysis strategy for C(sp3)-H hydroxylation and amidation using hypervalent iodine

We report a unified photoredox-catalysis strategy for both hydroxylation and amidation of tertiary and benzylic C-H bonds. Use of hydroxyl perfluorobenziodoxole (PFBl-OH) oxidant is critical for efficient tertiary C-H functionalization, likely due to the enhanced electrophilicity of the benziodoxole radical. Benzylic methylene C-H bonds can be hydroxylated or amidated using unmodified hydroxyl benziodoxole oxidant Bl-OH under similar conditions. An ionic mechanism involving nucleophilic trapping of a carbocation intermediate by H2O or CH3CN cosolvent is presented.