16405-99-5

Basic information

• Product Name: 4-(BROMOMETHYL)-2,1,3-BENZOTHIADIAZOLE
• Synonyms: 4-(BROMOMETHYL)-2,1,3-BENZOTHIADIAZOLE;4-(Bromomethyl)-2,1,3-benzothiadiazole ,97%;4-(bromomethyl)benzo[c][1,2,5]thiadiazole;4-Bromomethylbenzo[1,2,5]thiadiazole;2,1,3-Benzothiadiazole,4-(bromomethyl)-
• CAS NO: 16405-99-5
• Molecular Formula: C₇H₅BrN₂S
• Molecular Weight: 229.1
• EINECS: 604-604-1
• Mol File: 16405-99-5.mol
• Article Data: 8

Chemical Properties

• Melting Point: 89 °C
• Boiling Point: 299.3°Cat760mmHg
• Flash Point: 134.8°C
• Appearance: /
• Density: 1.776g/cm³
• Vapor Pressure: 0.00214mmHg at 25°C
• Refractive Index: 1.726
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-(BROMOMETHYL)-2,1,3-BENZOTHIADIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(BROMOMETHYL)-2,1,3-BENZOTHIADIAZOLE(16405-99-5)
• EPA Substance Registry System: 4-(BROMOMETHYL)-2,1,3-BENZOTHIADIAZOLE(16405-99-5)

Safety Data

• Hazard Codes: Xi,C,Xn
• Statements: 34-22
• Safety Statements: 26-36/37/39-45
• RIDADR: 3261
• Hazardous Substances Data: 16405-99-5(Hazardous Substances Data)

Usage

Chemical Properties

White crystal

InChI:InChI=1/C7H5BrN2S/c8-4-5-2-1-3-6-7(5)10-11-9-6/h1-3H,4H2

Upstream product

• 1457-92-7 4-Methyl-2,1,3-benzothiadiazol 
• 2687-25-4 3-methyl-1,2-benzenediamine 
• 570-24-1 2-Methyl-6-nitroaniline 

Downstream Products

• 16406-00-1 4-hydroxymethyl-2,1,3-benzothiadiazole 
• 273749-25-0 hydroxymethyl-para-phenylenediamine 
• 92061-28-4 2-(7-nitro-benzo[1,2,5]thiadiazol-4-yl)-N-phenyl-acetamide 
• 92164-36-8 2-benzo[1,2,5]thiadiazol-4-yl-N-phenyl-acetamide 
• 20032-78-4 3-benzo[1,2,5]thiadiazol-4-yl-2-(2-hydroxy-benzylideneamino)-propionic acid 
• 20032-79-5 4-(β-carboxy-β-amino)ethylbenzo-2,1,3-thiadiazole 
• 71605-60-2 trithiocarbonic acid bis-[2-(benzo[1,2,5]thiadiazol-4-ylmethyl-amino)-ethyl] ester 
• 71605-67-9 4,4'-(5,6-dithia-2,9-diaza-decane-1,10-diyl)-bis-benzo[1,2,5]thiadiazole 
• 151869-76-0 6-(2,3-diaminophenyl)-5-methyl-2,3,4,5-tetrahydro-pyridazin-3-one 
• 5170-68-3 benzo[c][1,2,5]thiadiazole-4-carbaldehyde 

Relevant articles and documents

Piperidine compound and preparation method and medical application thereof

The invention discloses a piperidine compound shown as a formula (I) and a preparation method and medical application thereof, and particularly relates to a piperidine USP7 inhibitor compound or pharmaceutically acceptable salt or ester or solvate thereof and a preparation method and application of the piperidine USP7 inhibitor compound or pharmaceutically acceptable salt or ester or solvate thereof. The compound provided by the invention can inhibit the activity of USP7 enzyme, has very good selectivity and druggability, and can be used for preparing medicines for preventing or treating tumor diseases or virus infectious diseases.

Microwave Assisted Synthesis of Trifluoro Substituted 2-Aminobenzimidazole Derivatives via Iodoacetic Acid Mediated One-pot Condensation

Microwave-assisted efficient one-pot syntheses of trifluoro substituted 2-aminobenzimidazole derivative were synthesized using iodoacetic acid mediated cyclodesulfurization of thioureas. This method eliminates need to handle preformed substituted thioureas, requires lesser reaction time and temperature, is facile, and also gives higher yields of the target molecules.

Synthesis and electronic and photophysical properties of [2.2]- and [3.3]paracyclophane-based donor-donor′-acceptor triads

Three types of the donor(D)-donor′(D′)-acceptor(A) triads 1-6 with different D-A combinations, carbazole (Cz, D)-[n.n]PCP(D′)-1,8-naphthalimide (NI, A) (1-3), 10H-phenothiazine (PTZ, D)-[n.n]PCP(D′)-NI(A) (4, 5), and 10-methyl-10H-phenothiazine (Me-PTZ, D)-[2.2]PCP-2,1,3-benzothiadiazole (BTD, A) 6, were synthesized for the elucidation of their photophysical properties. The absorption spectra and electrochemical properties indicated that the chromophores (D, D′, and A) do not interact with each other in the ground state. Cz-(CH2)3-[2.2]PCP-(CH2)3-NI 1 and Cz-(CH2)3-[3.3]PCP-(CH2)3-NI 2 show an exciplex emission between the PCP and NI moieties in cyclohexane and the intensity of the band is much higher in 2 than in 1, whereas Cz-(CH2)2-[2.2]PCP-(CH2)2-NI 3 does not show any exciplex emission in cyclohexane. These results indicated that the combination of [3.3]PCP and a trimethylene chain is preferable for the exciplex formation. PTZ-(CH2)3-[2.2]PCP-(CH2)3-NI 4 shows a broad band at 519 nm in cyclohexane, which is associated with the formation of the exterplex band among the NI, [2.2]PCP, and PTZ moieties, while PTZ-(CH2)3-[3.3]PCP-(CH2)3-NI 5 does not show the band. Me-PTZ-(CH2)2-[2.2]PCP-(CH2)2-BTD 6 shows a broad fluorescence band due to both the BTD and PTZ moieties in cyclohexane. In CH3CN, the fluorescence spectra of 1-6 suggest the presence of a photoinduced charge separation process. The study of the photoinduced charge separation process will be soon reported elsewhere.