16406-00-1

Basic information

• Product Name: 2,1,3-BENZOTHIADIAZOL-4-YLMETHANOL,97%
• Synonyms: 2,1,3-BENZOTHIADIAZOL-4-YLMETHANOL,97%;2,1,3-Benzothiadiazol-4-ylmethanol;Benzo[c][1,2,5]thiadiazol-4-ylMethanol
• CAS NO: 16406-00-1
• Molecular Formula: C₇H₆N₂OS
• Molecular Weight: 166.20034
• Mol File: 16406-00-1.mol
• Article Data: 5

Chemical Properties

• Melting Point: 112.6℃
• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2,1,3-BENZOTHIADIAZOL-4-YLMETHANOL,97%(CAS DataBase Reference)
• NIST Chemistry Reference: 2,1,3-BENZOTHIADIAZOL-4-YLMETHANOL,97%(16406-00-1)
• EPA Substance Registry System: 2,1,3-BENZOTHIADIAZOL-4-YLMETHANOL,97%(16406-00-1)

Safety Data

• Safety Statements: S24/25:Avoid contact with skin and eyes.
• Hazardous Substances Data: 16406-00-1(Hazardous Substances Data)

Upstream product

• 2687-25-4 3-methyl-1,2-benzenediamine 
• 1457-92-7 4-Methyl-2,1,3-benzothiadiazol 
• 570-24-1 2-Methyl-6-nitroaniline 
• 5170-68-3 benzo[c][1,2,5]thiadiazole-4-carbaldehyde 
• 151869-77-1 4-acetomethyl-2,1,3-benzothiadiazole 
• 19706-16-2 4-chloromethyl-2,1,3-benzothiadiazole 
• 16405-99-5 4-(bromomethyl)benzo[c][1,2,5]thiadiazole 
• 151869-78-2 4-dibromomethyl-2,1,3-benzothiadiazole 

Downstream Products

• 273749-25-0 hydroxymethyl-para-phenylenediamine 
• 151869-76-0 6-(2,3-diaminophenyl)-5-methyl-2,3,4,5-tetrahydro-pyridazin-3-one 
• 5170-68-3 benzo[c][1,2,5]thiadiazole-4-carbaldehyde 
• 5573-33-1 N'-benzo[1,2,5]thiadiazol-4-ylmethylene-N,N-dimethyl-benzene-1,4-diamine N'-oxide 
• 3529-57-5 benzo[1,2,5]thiadiazole-4-carboxylic acid 

Relevant articles and documents

SUBSTITUTED BENZIMIDAZOLES AS POTASSIUM CHANNEL INHIBITORS

The present invention relates to a compound of the general formula (I). The compounds of formula I are useful for treatment of a cardiac disease, disorder or condition in a mammal.

Cyclic bis-benzimidazole ligands and metal complexes thereof

Cyclic bis benzimidazole ligands of the following formula are formed by contacting a (2-aminophenyl)-benzimidazole-4-carboxaldehyde ethylene acetal or a (2-nitrophenyl)-benzimidazole-4-benzaldehyde with an acid optionally in the presence of a metal or a metal salt. wherein R1and R2may be the same or different and are selected from H, an alkyl having 1 to 10 carbon atoms, a benzyl group, a substituted 2-ethylphenyl group, a carbonyl group, a phenyl substituent, a tosyl group, and an alkylsulfonate group; R3and R4may be the same or different and are selected from H, methyl, and ethyl; and R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, and R18may be the same or different and are selected from H, alkyl having 1 to 10 carbon atoms, fluoride, chloride, bromide, iodide, nitro, amino, a carboxylate, an ester, and a phenyl group.

Synthesis of a new type of "bent" heterocyclic benzimidazolo-pyridazinones

The synthesis of some new heterocyclic benzimidazolo-pyridazinines starting from 2,1,3-benzothiadiazole-4-carboxaldehyde 2 is described.Biological evaluation of all new compounds proved them to be inhibitors of phosphodiesterase III with no marked positiv