164290-86-2Relevant academic research and scientific papers
Ru(II)-catalyzed ortho-amidation and decarboxylation of aromatic acids: A versatile route to meta-substituted N-aryl benzamides
Shi, Xian-Ying,Dong, Xue-Fen,Fan, Juan,Liu, Ke-Yan,Wei, Jun-Fa,Li, Chao-Jun
, p. 1286 - 1291 (2015)
Carboxylate as a promising and valuable directing group has attracted a great deal of attention. However, employing it as a traceless direction group has rarely been reported. We developed the ruthenium-catalyzed amidation of substituted benzoic acids wit
Interpositus substituted N-aryl benzoyl amines one-step synthesis method of the compound
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Paragraph 0017-0020; 0031-0034, (2017/02/28)
The invention discloses a one-step synthetic method of meta-substituted N-arylbenzamide compounds. Transition metal ruthenium is used as a catalyst, and the meta-substituted N-arylbenzamide compounds are synthesized in one step through carboxy-based o-C-H functionalization/ decarboxylation coupling reaction of aromatic acid and phenyl isocyanate compounds. The method has the advantages that the raw materials are simple and readily available, the catalyst is cheap, the reaction operation is simple, the utilization rate of atoms is high, the method is environment-friendly and the like.
Amine Activation: Synthesis of N-(Hetero)arylamides from Isothioureas and Carboxylic Acids
Zhu, Yan-Ping,Sergeyev, Sergey,Franck, Philippe,Orru, Romano V. A.,Maes, Bert U. W.
supporting information, p. 4602 - 4605 (2016/09/28)
A novel method for N-(hetero)arylamide synthesis based on rarely explored amine activation, rather than classical acid activation, is reported. The activated amines are easily prepared using a three-component reaction with commercial reagents. The new method shows a broad scope including challenging amides not (efficiently) accessible via classical protocols.
A convenient synthesis of N-aryl benzamides by rhodium-catalyzed ortho-amidation and decarboxylation of benzoic acids
Shi, Xian-Ying,Liu, Ke-Yan,Fan, Juan,Dong, Xue-Fen,Wei, Jun-Fa,Li, Chao-Jun
supporting information, p. 1900 - 1903 (2015/01/30)
The rhodium-catalyzed amidation of substituted benzoic acids with isocyanates by directed C-H functionalization followed by decarboxylation to afford the corresponding N-aryl benzamides is demonstrated, in which the carboxylate serves as a unique, removable directing group. Notably, less common meta-substituted N-aryl benzamides are generated readily from more accessible paraor ortho-substituted groups by employing this strategy.
Phosphine-free atmospheric carbonylation of aryl iodides with aniline derivatives in the presence of a reusable silica-supported palladium catalyst
Urbán, Béla,Papp, Máté,Srankó, Dávid,Skoda-F?ldes, Rita
, p. 150 - 157 (2015/02/19)
Various palladium catalysts were obtained by the immobilisation of palladium on silica, modified with imidazolium salts. The efficiency of the catalysts was greatly dependent on the choice of the anion of the imidazolium salt, the palladium precursor and on the conditions of heterogenisation. Palladium acetate immobilised on silica with grafted imidazolium chloride moieties was shown to be a selective and recyclable catalyst for atmospheric aminocarbonylation of aryl iodides with aromatic amines in DMF. It was proved that the greater loss of palladium in DMSO can be explained by the formation of soluble palladium complexes.
The influence of reaction conditions on the Diels-Alder cycloadditions of 2-thio-3-chloroacrylamides; Investigation of thermal, catalytic and microwave conditions
Kissane, Marie,Lynch, Denis,Chopra, Jay,Lawrence, Simon E.,Maguire, Anita R.
supporting information; experimental part, p. 5602 - 5613 (2011/02/18)
The Diels-Alder cycloadditions of cyclopentadiene and 2,3-dimethyl-1,3- butadiene to a range of 2-thio-3-chloroacrylamides under thermal, catalytic and microwave conditions is described. The influence of reaction conditions on the outcome of the cycloaddi
