16430-09-4

Basic information

• Product Name: 4-Benzylidene-3-methyl-2-isoxazoline-5-one
• Synonyms: 4-Benzylidene-3-methyl-2-isoxazoline-5-one;4-Benzylidene-3-methylisoxazol-5(4H)-one
• CAS NO: 16430-09-4
• Molecular Formula: C₁₁H₉NO₂
• Molecular Weight: 187.1947
• Mol File: 16430-09-4.mol
• Article Data: 32

Chemical Properties

• Melting Point: 146-147 °C
• Boiling Point: 292.1°Cat760mmHg
• Flash Point: 136.6°C
• Appearance: /
• Density: 1.16g/cm³
• Vapor Pressure: 0.00187mmHg at 25°C
• Refractive Index: 1.578
• CAS DataBase Reference: 4-Benzylidene-3-methyl-2-isoxazoline-5-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Benzylidene-3-methyl-2-isoxazoline-5-one(16430-09-4)
• EPA Substance Registry System: 4-Benzylidene-3-methyl-2-isoxazoline-5-one(16430-09-4)

Safety Data

• Hazardous Substances Data: 16430-09-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H9NO2/c1-8-10(11(13)14-12-8)7-9-5-3-2-4-6-9/h2-7H,1H3/b10-7-

Upstream product

• 932-90-1 syn-benzaldehyde oxime 
• 141-97-9 ethyl acetoacetate 
• 5435-44-9 (E)-3-Ureido-but-2-enoic acid ethyl ester 
• 5447-76-7 ethyl 3-oxobutanate oxime 
• 100-52-7 benzaldehyde 
• 105-45-3 acetoacetic acid methyl ester 
• 5470-11-1 hydroxylamine hydrochloride 
• 1517-96-0 3-methyl-5-isoxazolone 
• 7647-01-0 hydrogenchloride 
• 68708-10-1 2-(1-hydroxyimino-ethyl)-3-phenyl-acrylic acid 
• 64-17-5 ethanol 
• 620-80-4 ethyl 2-benzylidene acetoacetate 
• 86119-84-8 phosphoric acid 
• 932-90-1 Benzaldoxime 

Relevant articles and documents

Fruit Extract of Averrhoa bilimbi: A Green Neoteric Micellar Medium for Isoxazole and Biginelli-Like Synthesis

A transition metal/ligand/additive/promoter-free synthesis of 3-methyl-4-arylmethylene-isoxazol-5(4H)-ones and the Biginelli-like synthesis is carried out in a natural acidic medium of Averrhoa bilimbi extract (ABE) with cleaner and facile approach smenti

Facile and expedient synthesis of α,β-unsaturated isoxazol-5(4H)-ones under mild conditions

Abstract: It was found that nano-SiO2–H2SO4 was catalyzed by the three-component cyclocondensation of aryl/heteroaryl aldehydes, hydroxylamine hydrochloride, and β-ketoesters toward the synthesis of α,β-unsaturated?isoxazol-5(4H)-ones under green conditions. The reaction yielded the corresponding heterocycles at room temperature in relatively shorter reaction times. It merits mentioning that the mild conditions allow the synthesis of several α,β-unsaturated?isoxazol-5(4H)-ones using this method. In this study, some new derivatives of isoxazolones were also synthesized and characterized. It is efficient, clean, simple, safe, and ecologically friendly. This straightforward method is cost-effective and requires no preparation of reactants. The three-component annulation was performed without using energy sources, for example, heat, ultrasound wave, and microwave irradiation. Graphic abstract: [Figure not available: see fulltext.].

An improved protocol for the synthesis of 3,4-disubstituted isoxazol-5(4H)-ones through L-valine-mediated domino three-component strategy

Abstract: An expeditious, metal-free protocol has been demonstrated for the synthesis of isoxazolone derivatives using domino multi-component strategy. The envisaged methodology involves the L-valine promoted three-component cyclo-condensation reaction of