164347-63-1

Upstream product

• 364-83-0 2',4'-difluoroacetophenone 
• 2181-42-2 trimethylsulphonium iodide 
• 51336-94-8 2-chloro-1-(2,4-dichlorophenyl)ethanone 
• 74-95-3 1,1-dibromomethane 

Downstream Products

• 1037740-27-4 1-(1-benzyl-4-methylpiperidin-4-yl)-6-fluoro-3-methyl-1H-indole 
• 1037739-88-0 1-(1-benzylpiperidin-4-yl)-6-fluoro-3-methyl-1H-indole 
• 64951-43-5 N-(1-benzylpiperidin-4-yl)formamide 
• 2425-74-3 t-butylformamide 
• 1037740-13-8 1-tert-butyl-6-fluoro-3-methyl-1H-indole 
• 1037739-92-6 1-{1-[(benzyloxy)methyl]propyl}-6-fluoro-3-methyl-1H-indole 
• 1037739-96-0 2-(6-fluoro-3-methyl-1H-indol-1-yl)-2-phenylethanol 
• 1283086-97-4 C₂₃H₂₄F₂N₂O 

Relevant academic research and scientific papers

Continuous Flow Synthesis of Terminal Epoxides from Ketones Using in Situ Generated Bromomethyl Lithium

A scalable procedure for the direct preparation of epoxides from ketones has been developed. The method is based on the carefully controlled generation of (bromomethyl)lithium (LiCH2Br) from inexpensive CH2Br2 and MeLi in a continuous flow reactor. The reaction has shown excellent selectivity for a variety of substrates, including α-chloroketones, which typically fail under classic Corey-Chaykovsky conditions. This advantage has been used to develop a novel route toward the drug fluconazole.

AZEPINO [4, 5-B] INDOLES AND METHODS OF USE

This disclosure relates to new azepino[4,5-b]indole compounds that may be used to modulate a histamine receptor in an individual. Novel compounds are described, including new 1, 2,3,4,5, 6-tetrahydroazepino[4,5-b]indoles. Pharmaceutical compositions are also provided.

PYRIDO (4,3-B) INDOLES CONTAINING RIGID MOIETIES

This disclosure is directed to pyrido[4,3-b]indoles having rigid moieties. The compounds in one embodiment are pyrido[4,3-b]indoles having an unsaturated hydrocarbon moiety. The compounds in another embodiment are pyrido[4,3-b]indoles having a cycloalkyl, cycloalkenyl or heterocyclyl moiety. Pharmaceutical compositions comprising the compounds are also provided, as are methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and/or a neuronal disorder.

Microwave-assisted synthesis of N-sec- and N-tert-alkylated indoles

A synthesis of N-substituted indoles by means of an epoxide-opening, nucleophilic aromatic substitution, and dehydration sequence is reported, which is capable of generating even N-tert alkyl substituted derivatives. Georg Thieme Verlag Stuttgart.