16442-59-4Relevant articles and documents
Experimental and theoretical investigation of substituent effects in a two-pathway reaction of tetrahydro-1,5-benzodiazepine-2-thiones with 4-substituted 2-bromoacetophenones
Janciene, Regina,Vektariene, Ausra,Stumbreviciute, Zita,Puodziunaite, Benedikta
, p. 609 - 618 (2011)
The interaction of 5-acetyl(or formyl)-3-R1(CH3, H)-4-R2(CH3, Ph, H)-1,3,4,5-tetrahydro-2H-1,5- benzodiazepine-2-thiones with 2-bromo-4′-X(CH3, OCH 3, Br, H)-acetophenones leads to a mixture of products: 5,6-dihydro-4H-[1,3]thiazolo[3,2-a][1,5]benzodiazepinium salts and S-[2-oxo-2-(4-X-phenyl)ethyl] 3-(1H-benzimidazol-1-yl)propane(or butane-)thioate hydrobromides. The course of the concurrent reactions depends on the presence of substituents of the starting thiones and on the nature of the 4-substituent of the bromoacetophenones. Semiempirical Austin method 1 (AM1) and density functional theory (DFT) B3LYP computational studies for the interpretation of two concurrent reaction pathways are presented.
TRANSFORMATION OF DIHYDRO-1,5-BENZODIAZEPIN-2-ONES UNDER THE INFLUENCE OF ACETIC ANHYDRIDE
Puodzhyunaite, B. A.,Yanchene, R. A.,Terent'ev, P. B.
, p. 311 - 317 (2007/10/02)
The acylation of 4-R-2,3-dihydro-1H-1,5-benzodiazepin-2-ones leads to isomerization or opening of the heteroring with subsequent acylation. 1-Acyl-2,3-dihydro-1,5-benzodiazepin-2-ones are not formed.