1644247-82-4Relevant academic research and scientific papers
Direct fluoroalkylation of indoles with fluoroalkyl halides mediated by copper
He, Ru-Yi,Zeng, Hui-Ting,Huang, Jing-Mei
, p. 4258 - 4263 (2014)
An efficient and mild copper-mediated reaction for the direct perfluoroalkylation and difluoromethylation of indoles with perfluoroalkyl halides and ICF2COOEt to produce 2-substituted indoles was developed. Both free indole derivatives and N-su
Palladium-catalyzed C-H ethoxycarbonyldifluoromethylation of electron-rich heteroarenes
Shao, Changdong,Shi, Guangfa,Zhang, Yanghui,Pan, Shulei,Guan, Xiaohong
supporting information, p. 2652 - 2655 (2015/06/16)
The first Pd-catalyzed C-H ethoxycarbonyldifluoromethylation with BrCF2CO2Et has been developed. The use of a bidentate phosphine ligand (Xantphos) is critical for the reaction to occur. A variety of electron-rich heteroarenes, including indoles, furans, thiophenes, and pyrroles, can be ethoxycarbonyldifluoromethylated in moderate to excellent yields. The reactions take place at the C-H bonds adjacent to the heteroatoms with high regioselectivity. This method provides a new protocol for the introduction of difuoroalkyl groups into electron-rich heteroarenes.
