3135-63-5Relevant academic research and scientific papers
STUDIES ON TRIFLUOROMETHYLPHOSPHONAMIDITE ANALOGUES AS BUILDING BLOCKS IN OLIGONUCLEOTIDE SYNTHESIS
Mayer, Michael,Ugi, Ivar,Richter, Wolfgang
, p. 2047 - 2050 (2007/10/02)
The phosphorylating reagents CF3P(NMe2)Cl and CF3P(NEt2)Cl are used to phosphorylate the 3'-hydroxyl moiety of several protected 2'-deoxynucleosides yielding the corresponding nucleoside trifluoromethyl phosphonamidites.Their scope and limitations towards amidite activation are investigated but, however, their behavior is completely different to commonly used nucleoside phosphorus amidites.
