165191-71-9Relevant academic research and scientific papers
Improved Syntheses of Benzyl Hydraphile Synthetic Cation-Conducting Channels
Curvey, Nichole S.,Luderer, Sarah E.,Walker, John K.,Gokel, George W.
, p. 2771 - 2779 (2015/02/19)
The tris(macrocycle)s that function in bilayer membranes as ion channels have recently shown versatile new applications such as antibiotic synergists and as agents for direct injection chemotherapy. This report records the development of new and versatile approaches to these molecules that produce significantly better overall yields for a group of previously reported hydraphiles having spacer chains ranging from octylene to hexadecylene.
Synthetic models for transmembrane channels: Structural variations that alter cation flux
Murillo, Oscar,Watanabe, Shigeru,Nakano, Akio,Gokel, George W.
, p. 7665 - 7679 (2007/10/03)
Twelve novel bis- or tris(macrocyclic) compounds have been designed as models for cation-conducting channels that function in phospholipid bilayer vesicle membranes. In general, the channel model systems have the structure "sidearm-crown-spacer-crown-spac
