16566-20-4

Basic information

• Product Name: QUINOXALIN-5-AMINE
• Synonyms: 5-AMINO-QUINOXALINE;QUINOXALIN-5-AMINE;5-amino-quinoxalin;5-quinoxalinamine;Quinoxalin-5-amine, 5-Amino-1,4-benzodiazine
• CAS NO: 16566-20-4
• Molecular Formula: C₈H₇N₃
• Molecular Weight: 145.16
• Product Categories: Amines;Quinolines, Isoquinolines & Quinoxalines;Quinolines, Isoquinolines & Quinoxalines
• Mol File: 16566-20-4.mol
• Article Data: 13

Chemical Properties

• Melting Point: 92 °C
• Boiling Point: 323.7 °C at 760 mmHg
• Flash Point: 175.7 °C
• Appearance: /
• Density: 1.292 g/cm³
• Vapor Pressure: 0.000257mmHg at 25°C
• Refractive Index: 1.723
• PKA: 2.57±0.30(Predicted)
• CAS DataBase Reference: QUINOXALIN-5-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: QUINOXALIN-5-AMINE(16566-20-4)
• EPA Substance Registry System: QUINOXALIN-5-AMINE(16566-20-4)

Safety Data

• Hazardous Substances Data: 16566-20-4(Hazardous Substances Data)

Usage

General Description

Quinoxalin-5-amine is a chemical compound with the molecular formula C8H7N3. It is a derivative of quinoxaline, a heterocyclic compound that contains a ring structure consisting of one nitrogen and two carbon atoms. Quinoxalin-5-amine is used in the synthesis of various pharmaceuticals, including antitumor agents, antiviral drugs, and antibiotics. It also has potential applications in the development of new materials and organic electronic devices. Quinoxalin-5-amine is considered to be a versatile building block in organic chemistry due to its reactivity and ability to participate in a variety of chemical reactions.

InChI:InChI=1/C8H7N3/c9-6-2-1-3-7-8(6)11-5-4-10-7/h1-5H,9H2

Upstream product

• 608-32-2 1,2,3-triaminobenzene 
• 517-21-5 glyoxal sodium bisulfite 
• 26556-23-0 N-quinoxalin-5-yl-acetamide 
• 496-45-7 glyoxal sulfate 
• 66046-54-6 1,2,3-triaminobenzene dihydrochloride 
• 18514-76-6 5-nitrobenzopyrazine 
• 131543-46-9 Glyoxal 
• 3694-52-8 2,3-diamino-nitrobenzene 
• 141-43-5 ethanolamine 
• 767-63-5 2,1,3-benzooxadiazol-4-ylamine 

Downstream Products

• 792189-09-4 N-acetyl-sulfanilic acid quinoxalin-5-ylamide 
• 844646-88-4 quinoxaline-5-sulfonyl chloride 

Relevant articles and documents

Quinoxalines useful as cytoprotective agents

Provided herein are compounds of Formula I, pharmaceutical compositions thereof, and methods of their use for treating, preventing, or ameliorating one or more symptoms of a neurological disease, neurodegenerative disorder, or diabetes.

Preparation method of benzopyridazine derivative

The invention discloses a preparation method of a benzopyridazine derivative 5-bromobenzopyridazine; 1,2-diamino-3-nitrobenzene as a starting raw material is subjected to cyclization, reduction and Sandmeryer reaction to obtain the target product; the compound is an important pharmaceutical intermediate.

6,6-Fused heterocyclic ureas as highly potent TRPV1 antagonists

A series of N-[{2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)-pyridin-3-yl}methyl] N′-(6,6-fused heterocyclic) ureas have been investigated as hTRPV1 antagonists. Among them, compound 15 showed highly potent TRPV1 antagonism to capsaicin, with Ki(ant) = 0.2 nM, as well as antagonism to other activators, and it was efficacious in a pain model. A docking study of 15 with our hTRPV1 homology model indicates that there is crucial hydrogen bonding between the ring nitrogen and the receptor, contributing to its potency.