165673-78-9Relevant academic research and scientific papers
Synthesis of a novel 4,6′-epoxymorphinan derivative and a highly strained novel conjugated ketone
Nemoto, Toru,Fujii, Hideaki,Sato, Noriko,Nagase, Hiroshi
, p. 7413 - 7417 (2007)
A modification of the 4,5-epoxymorphinan skeleton of naltrexone was carried out to improve the potency and the selectivity of the ligand for an opioid receptor subtype. As one of the modified structures, we newly designed and synthesized a novel 7-membere
Syntheses of 4,6′-epoxymorphinan derivatives and their pharmacologies
Nemoto, Toru,Fujii, Hideaki,Narita, Minoru,Miyoshi, Kan,Nakamura, Atsushi,Suzuki, Tsutomu,Nagase, Hiroshi
, p. 4304 - 4312 (2008/12/20)
A modification of the message site in the skeleton of naltrexone was carried out to improve the potency and selectivity of the compound for an opioid receptor subtype. In the course of conversion, we synthesized 7-membered ring ether derivatives, which ha
Synthesis and Biological Evaluation of 14-Alkoxymorphinans. 11. 3-Hydroxycyprodime and Analogues: Opioid Antagonist Profile in Comparison to Cyprodime
Schmidhammer, Helmut,Jennewein, Herwig K.,Krassnig, Roland,Traynor, John R.,Patel, Dinesh,et al.
, p. 3071 - 3077 (2007/10/03)
A series of 3-hydroxy-substituted analogues (3-7) of the μ selective opioid antagonist cyprodime has been synthesized in order to evaluate the role of a hydroxy group at C-3 concerning μ opioid antagonist selectivity.Compounds 3-7 were tested in bioassays
