Synthesis of a novel 4,6′-epoxymorphinan derivative and a highly strained novel conjugated ketone

DOI: 10.1016/j.tetlet.2007.07.194

Source and publish data:

Tetrahedron Letters p. 7413 - 7417 (2007)

Update date:2022-08-03

Topics:

Authors:

Nemoto, Toru

Fujii, Hideaki

Sato, Noriko

Nagase, Hiroshi

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Article abstract of DOI:10.1016/j.tetlet.2007.07.194

A modification of the 4,5-epoxymorphinan skeleton of naltrexone was carried out to improve the potency and the selectivity of the ligand for an opioid receptor subtype. As one of the modified structures, we newly designed and synthesized a novel 7-membere

Full text of DOI:10.1016/j.tetlet.2007.07.194

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