1657-84-7

Upstream product

• 860734-15-2 2-methoxy-4-(methylsulfanyl)-1-nitrobenzene 
• 2388-74-1 1-methoxy-3-methylsulfanyl-benzene 
• 90-04-0 2-methoxy-phenylamine 
• 67-68-5 dimethyl sulfoxide 
• 680214-26-0 bis-(3-methoxy-4-nitro-phenyl)-disulfide 
• 6627-53-8 1-chloro-3-methoxy-4-nitrobenzene 
• 611-07-4 5-chloro-2-nitrophenol 
• 95420-72-7 4-mercapto-2-methoxybenzoic acid 
• 1657-83-6 2',4'-Dinitro-2-methoxy-4-methylmercapto-azobenzol 
• 72856-73-6 2-methoxy-4-(methylsulfanyl)benzoic acid 

Relevant academic research and scientific papers

Highly regioselective para-methylthiolation/bridging methylenation of arylamines promoted by NH4I

Aryl methyl thioethers and methylene-bridged arylamines were synthesized via highly regioselective para-methylthiolation/bridging methylenation of arylamines using DMSO as the methylthio or methylene source in the presence of NH4I under metal-free conditions. For the substrates with both electron-donating and electron-withdrawing substituents, the reaction proceeded smoothly and gave moderate to good yields.

Synthesis and anti-inflammatory activity of antioxidants, 4-alkylthio-o-anisidine derivatives

In order to search for anti-inflammatory agents against autoimmune diseases, we synthesized 4-alkylthio-o-anisidine derivatives possessing antioxidant activity, and tested them for anti-inflammatory activity against the Arthus reaction in mice. Experimental inflammations, including the Arthus reaction, concanavalin A, phorhol ester and pyrophosphate-induced edemas in rats were inhibited by 4-propylthio-o-anisidine, which inhibited autoxidation of rat brain homogenate and suppressed the lipopolysaccharide-induced increase in the plasma malondialdehyde level in mice. An antioxidant may be an effective agent in immune complex type inflammation where active oxygen species play an important role.