611-07-4

Usage

Uses

Used in Dye Manufacturing:
5-Chloro-2-nitrophenol is used as a key intermediate in the synthesis of various dyes. Its unique chemical structure allows for the creation of a wide range of colors, making it a valuable component in the dye industry.
Used in Pharmaceutical Production:
In the pharmaceutical industry, 5-Chloro-2-nitrophenol serves as an essential intermediate for the development of certain drugs. Its chemical properties enable the synthesis of pharmaceutical compounds with specific therapeutic effects.
Used in Agricultural Chemicals:
5-Chloro-2-nitrophenol is also utilized in the production of agricultural chemicals, such as pesticides and herbicides. Its ability to react with other compounds makes it a useful building block for creating effective agricultural products.
Used as an Intermediate in Organic Compounds Synthesis:
Due to its reactivity, 5-Chloro-2-nitrophenol is employed as an intermediate in the synthesis of other organic compounds. Its versatility in chemical reactions allows for the creation of various organic molecules with different applications.
Safety Precautions:
As a hazardous substance, 5-Chloro-2-nitrophenol can cause irritation to the skin, eyes, and respiratory system. It is crucial to handle and store this chemical with proper safety measures, such as wearing protective gear and using appropriate containment methods, to minimize potential health risks.

InChI:InChI=1/C6H4ClNO3/c7-4-1-2-5(8(10)11)6(9)3-4/h1-3,9H

Upstream product

• 108-43-0 3-monochlorophenol 
• 100-00-5 4-chlorobenzonitrile 
• 7732-18-5 water 
• 108-42-9 3-chloro-aniline 
• 7697-37-2 nitric acid 
• 64-17-5 ethanol 
• 7664-93-9 sulfuric acid 
• 64-19-7 acetic acid 
• 84437-61-6 benzyl-(5-chloro-2-nitro-phenyl)-ether 
• 860602-54-6 (5-chloro-2-nitro-phenyl)-arsonic acid 
• 611-06-3 2,4-dichloronitrobenzene 
• 28373-39-9 2-(3-chlorophenoxy)pyridine 
• 5131-58-8 2,4-diaminonitrobenzene 
• 118-83-2 5-chloro-2-nitrotrifluoromethylbenzene 

Downstream Products

• 1706-82-7 3-chloro-2,4,6-trinitro-phenol 
• 54715-57-0 5-chloro-2,4-dinitrophenol 
• 858854-93-0 4,6-dibromo-3-chloro-2-nitro-phenol 
• 54715-56-9 3-chloro-2,6-dinitro-phenol 
• 28443-50-7 2-amino-5-chlorophenol 
• 16323-09-4 N-(4-chloro-2-hydroxyphenyl)acetamide 
• 6627-53-8 1-chloro-3-methoxy-4-nitrobenzene 
• 40422-90-0 4-chloro-1-nitro-2-(propan-2-yloxy)benzene 
• 65001-78-7 4-bromo-5-chloro-2-nitrophenol 
• 907587-43-3 methyl 4-[(5-chloro-2-nitrophenoxy)methyl]benzoate 
• 175135-19-0 AMA₅₆ 
• 2380-84-9 7-Indolol 
• 3189-22-8 7-methoxy-1H-indole 
• 111795-91-6 (5-chloro-3-methoxy-2-nitrophenyl)acetonitrile 

Relevant academic research and scientific papers

Method for hydrolyzing nitroaniline substances into phenol

The invention discloses a method for hydrolyzing nitroaniline substances into phenol. The method comprises the following steps: mixing the nitroaniline substances, a catalyst and inorganic base whichare used as raw materials with water used as a solvent, adding the mixture to a reactor, sealing the reactor, and heating the reactor to 100-190 DEG C for a reaction for 2-8 h; cooling an obtained reaction solution to room temperature, then, adjusting pH to 1-2, and washing and drying obtained precipitates to obtain the product, namely, nitrophenol substances. The nitrophenol substances are synthesized with the method, the utilization rate of the raw materials is high, expensive catalysts are not used, emission of three wastes is reduced, the production cost is reduced, and the product has high purity, high yield and good industrial application values.

Highly efficient protocol for the aromatic compounds nitration catalyzed by magnetically recyclable core/shell nanocomposite

An efficient protocol for the nitration of aromatic compounds in the presence of a catalytic amount of sulfuric acid-functionalized silica-based magnetic core/shell nanocomposite was reported. The designed products were obtained in high yields in relatively short reaction times at room temperature under solvent-free conditions. The nanocatalyst was simply recovered from the reaction mixture by using an external magnet and efficiently reused for several times. The characterization of particle size, morphology and elemental analysis of the nanocatalyst were provided by scanning electron microscopy, transmission electron microscopy and energy-dispersive X-ray spectroscopy analyses, respectively.

A ortho-nitro phenol and its derivative synthesis method (by machine translation)

The invention relates to a method for the synthesis of organic compounds, in the existing technology of O-nitrophenol strong acid used in the synthesis process of the serious problem of environmental pollution and the synthesis step longer more complicated problem, the invention provides a ortho-nitro phenol and synthetic method of derivative thereof, proceeding by the phenol compound, synthesis of 2 - (phenoxy) pyridine, the obtained product, catalyst, tert-butyl nitrite, organic solvent and adding sealing in the pressure containers, in oil bath heating 50 - 100 °C, reaction 10 - 30 hours, to obtain 2 - (2 - nitrobenzene) ethoxy pyridine; re-processing by the ortho-nitro phenol and its derivatives; the method is simple, high-efficiency. (by machine translation)

Spiro aryl phosphorus oxide or sulfide

The invention discloses a spiro aryl phosphorus oxide or sulfide as ALK inhibitor, and in particular discloses a compound shown in a formula (I) as an ALK inhibitor or a pharmaceutically acceptable salt thereof.

An ortho-nitro phenol synthetic method of compound

The invention relates to a synthesis method of o-nitrophenol compounds, solving the problems that production hazards are easily caused due to the release of a large deal of heat during the synthesis of o-nitrophenol and the severe environment pollution caused due to the generation of a large deal of waste gas and acid in the process in the prior art. The invention provides the synthesis method of the o-nitrophenol compounds, which comprises the steps: synthesizing 2-(phenoxy)pyridine from phenol compounds; and then sequentially adding 2-(phenoxy)pyridine and a catalyst, a nitrating reagent, an oxidant and an organic solvent into a sealed pressure container, heating and reacting for 10-50 hours in an oil bath of which the temperature is 80 DEG C-130 DEG C to obtain 2-(2-nitrophenyl)oxy pyridine; and finally treating to obtain o-nitrophenol. The synthesis method is simple, convenient and efficient.

COMBINATION THERAPIES FOR TREATMENT OF CANCER

Combination therapies for treatment of cancers associated with mutations in the KRAS gene are provided. Compositions comprising therapeutic agents for treatment of cancers associated with mutations in the KRAS gene are also provided.

Palladium-catalyzed aromatic C-H bond nitration using removable directing groups: Regiospecific synthesis of substituted o -nitrophenols from related phenols

A general and regiospecific transformation of substituted phenols into the related o-nitrophenols has been achieved via a three-step process involving the palladium-catalyzed chelation-assisted ortho-C-H bond nitration as the key step. In the process, 2-pyridinyloxy groups act as removable directing groups for the palladium-catalyzed ortho-nitration of substituted 2-phenoxypridines, and they can be readily removed in the subsequent conversion of the resulting 2-(2-nitrophenoxy)pyridines into 2-nitrophenols.

COVALENT INHIBITORS OF KRAS G12C

Irreversible inhibitors of G12C mutant K-Ras protein are provided. Also disclosed are methods to modulate the activity of G12C mutant K-Ras protein and methods of treatment of disorders mediated by G12C mutant K-Ras protein.

A probable hydrogen-bonded meisenheimer complex: An unusually high S NAr reactivity of nitroaniline derivatives with hydroxide ion in aqueous media

Observations show that nitroanilines exhibit an unusually high S NAr reactivity with OH- in aqueous media in reactions that produce nitrophenols. SNAr reaction of 4-nitroaniline (2a) in aqueous NaOH for 16 h yields 4-nitrophenol (4a) quantitatively, whereas a similar reaction of 4-nitrochlorobenzene (1a) gave 4a in 2% yield together with recovered 1a in 97%, suggesting that the leaving ability of the NH2 group far surpasses that of Cl under these conditions. An essential feature of SNAr reactions of nitroanilines is probably that the NH2 leaving group participates in a hydrogen-bonding interaction with H 2O. Density functional theory (DFT) calculations for a set of 4-nitroaniline, OH-, and H2O suggest a possible formation of a Meisenheimer complex stabilized by hydrogen-bonding interactions and a six-membered ring structure. The results obtained here contrast with conventional SNAr reactivity profiles in which nitroanilines are nearly unreactive with nucleophiles in organic solvents.

SAR studies of pyridazinone derivatives as novel glucan synthase inhibitors

A novel series of pyridazinone analogs has been developed as potent β-1,3-glucan synthase inhibitors through structure-activity relationship study of the lead 5-[4-(benzylsulfonyl)piperazin-1-yl]-4-morpholino-2-phenyl- pyridazin-3(2H)-one (1). The effect of changes to the core structure is described in detail. Optimization of the sulfonamide moiety led to the identification of important compounds with much improved systematic exposure while retaining good antifungal activity against the fungal strains Candida glabrata and Candida albicans.