1658-03-3

Upstream product

• 90005-98-4 (5-methoxy-2-nitrophenyl)(methyl)sulfane 
• 1657-85-8 (2,4-dinitro-phenyl)-(4-methoxy-2-methylsulfanyl-phenyl)-diazene 
• 1747-60-0 6-methoxybenzothiazol-2-ylamine 
• 74-88-4 methyl iodide 
• 491-11-2 3-chloro-4-nitrophenol 
• 2388-74-1 1-methoxy-3-methylsulfanyl-benzene 
• 28987-59-9 3-chloro-4-nitroanisole 
• 35350-40-4 bis-(5-methoxy-2-nitro-phenyl)-disulfide 
• 104-94-9 4-methoxy-aniline 
• 624-92-0 Dimethyldisulphide 

Downstream Products

• 92014-01-2 2-phenyl-6-methoxybenzothiophene 
• 63675-74-1 2-(4'-methoxyphenyl)-6-methoxybenzothiophene 

Relevant academic research and scientific papers

Facile syntheses of 3-trifluoromethylthio substituted thioflavones and benzothiophenes via the radical cyclization

3-CF3S substituted thioflavones and benzothiophenes were achieved via the reactions of AgSCF3 with methylthiolated alkynones and alkynylthioanisoles, respectively, promoted by persulfate. This protocol possesses good functional group tolerance and high yields. Mechanistic studies suggested that a classic two-step radical process was involved, which includes addition of CF3S radical to triple bond and cyclization with SMe moiety.

Preparation of Benzothiophenes and Benzoselenophenes from Arylamines and Alkynes via Radical Cascade Reactions

An intermolecular radical cascade reaction between readily prepared o-methylthio-arylamines or o-methylselanyl-arylamines and alkynes for the preparation of valuable benzothiophenes or benzoselenophenes is reported. These transformations occur efficiently with complete regioselectivity and the products are obtained in moderate to good yields. The current protocol is successfully applied to the synthesis of the key intermediates of the drug raloxifene and an AT1receptor antagonist.

Visible light photocatalytic synthesis of benzothiophenes

The photocatalytic reaction of o-methylthio-arenediazonium salts with alkynes yields substituted benzothiophenes regioselectively through a radical annulation process. Green light irradiation of eosin Y initiates the photoredox catalysis. The scope of the reaction was investigated by using various substituted diazonium salts and different alkynes.

Positive allosteric modulators of the nicotinic acetylcholine receptor

The invention provides compounds of Formula I: These compounds may be in the form of pharmaceutical salts or compositions, may be in pure enantiomeric form or racemic mixtures, and are useful in pharmaceuticals used to treat diseases or conditions in which α7 nAChR is known to be involved.

Sulfur-alkyne cyclizations for formation of dihydrothiophenes and annulated thiophenes

Cycloisomerization of homopropargylic thiols to dihydrothiophenes is promoted by group VI metal carbonyls. Related thiacyclization transformations under basic and radical conditions are also described, including regioselective formation of benzothiophenes from aryl methyl sulfides and alkynes.