165817-82-3Relevant articles and documents
Synthesis of an anti-methicillin-resistant Staphylococcus aureus (MRSA) carbapenem via stannatrane-mediated Stille coupling.
Jensen,Yang,Hsiao,Rivera,Wells,Chung,Yasuda,Hughes,Reider
, p. 1081 - 1084 (2000)
[formula: see text] A short synthesis of carbapenem 1 is described. They key step involves the cross-coupling of an enol triflate with an amino-substituted sp3 carbon. This cross-couping, which allows the introduction of the complete side chain in one ste
FLUORESCENT CARBAPENEMS
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Paragraph 0070; 0074; 0079, (2013/05/08)
Chromogenic or fluorescent carbapenems according to formula I, wherein Ar is a mono or disubstituted carbocyclic aromatic group or an optionally mono or disubstituted heterocyclic aromatic group, are useful compounds for the detection of bacterial carbape
Crystalline 2-hydroxymethyl carbapenem intermediate compounds and process for synthesis thereof
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Page column 8, (2010/11/29)
A process for preparation of a compound of formula I: wherein: R1represents CH3or H; and P represents a protecting group; comprising reacting a compound of formula IV: ?wherein R1and P and are defined above and R4/su
Practical synthesis of anti-methicillin-resistant Staphylococcus aureus (MRSA) carbapenem L-742,728
Yasuda, Nobuyoshi,Huffman, Mark A.,Ho, Guo-Jie,Xavier, Lyndon C.,Yang, Chunhua,Emerson, Khateeta M.,Tsay, Fuh-Rong,Li, Yulan,Kress, Michael H.,Rieger, Dale L.,Karady, Sandor,Sohar, Paul,Abramson, Newton L.,DeCamp, Ann E.,Mathre, David J.,Douglas, Alan W.,Dolling, Ulf-H.,Grabowski, Edward J. J.,Reider, Paul J.
, p. 5438 - 5446 (2007/10/03)
Anti-MRSA carbapenem, L-742,728, has been prepared in large quantity using the Suzuki-Miyaura cross-coupling as the key reaction. Three approaches have been examined by varying the coupling reaction between carbapenem nucleus A and side chains B, BC, and