16610-81-4Relevant articles and documents
Synthesis of non-symmetrical 3,4-diaryl-substituted pyrroles: Implementation for the preparation of lamellarin R
Zavala-Gómez, Héctor,Ramírez-Rodríguez, Armando,Vázquez, Alfredo
, p. 677 - 683 (2018/01/08)
A straightforward method for synthesising symmetrical and non-symmetrical 3,4-diaryl-substituted pyrroles is proposed, consisting of (i) the condensation reaction between phenylacetonitriles and aldehydes to give acrylonitriles, (ii) the conjugate additio
A process for preparing two aromatic ring substituted olefins method
-
Paragraph 0049-0051, (2017/06/08)
The invention relates to an efficient environment-friendly catalyst, and a new method for preparing double-(hetero)aromatic-ring substituted alkene under a room-temperature condition by taking water as a reaction medium. The method comprises: taking n-propylamine supported by super-paramagnetism nanometer particles and modified by ion atmosphere as a catalyst, and under the conditions of room temperature, normal pressure and water reaction medium, performing Knoevenagel condensation reaction on an (hetero)aromatic-ring substituted active alkene substance and an aromatic aldehyde, so as to obtain a corresponding double-(hetero)aromatic-ring substituted alkene derivative. The reaction yield is not obviously reduced after the supported catalyst is repeatedly used for 8 times. The method is simple in operation, high in yield, simple in catalyst recovery, good in reusability of the catalytic reaction system and mild in reaction conditions, and has good industrialization prospect.
Design of Bcl-2 and Bcl-xL inhibitors with subnanomolar binding affinities based upon a new scaffold
Zhou, Haibin,Chen, Jianfang,Meagher, Jennifer L.,Yang, Chao-Yie,Aguilar, Angelo,Liu, Liu,Bai, Longchuan,Cong, Xin,Cai, Qian,Fang, Xueliang,Stuckey, Jeanne A.,Wang, Shaomeng
experimental part, p. 4664 - 4682 (2012/07/28)
Employing a structure-based strategy, we have designed a new class of potent small-molecule inhibitors of the anti-apoptotic proteins Bcl-2 and Bcl-xL. An initial lead compound with a new scaffold was designed based upon the crystal structure of Bcl-xL an
