16629-89-3

Upstream product

• 75-69-4 trichlorofluoromethane 
• 100-52-7 benzaldehyde 
• 75-43-4 Dichlorofluoromethane 
• 865-47-4 potassium tert-butylate 

Downstream Products

• 384-66-7 2,2-dichloro-2-fluoro-1-phenylethanone 
• 16629-99-5 (E)-β-chloro-β-fluorostyrene 
• 16629-98-4 (Z)-β-chloro-β-fluorostyrene 
• 82255-41-2 (R)-(-)-2-fluoro-1-phenylethanol 
• 447-15-4 α-chloro-α-fluoroacetophenone 
• 450-95-3 2-fluoroacetophenone 
• 16629-93-9 β-Fluor-α,β,β-trichlorethylbenzol 

Relevant academic research and scientific papers

Addition of CFCl3 to aromatic aldehydes under ultrasonic irradiation

Reductive addition of CFCl3 to aromatic aldehydes under the influence of activated aluminum powder and ultrasonic irradiation produced chlorofluoro carbinols in reasonable to excellent yields. Georg Thieme Verlag Sttugart.

Effective nucleophilic trifluoromethylation with fluoroform and common base

Common bases (alcoholate, dimsyl anion or amide) are able to deprotonate trifluoromethane to form a trifluoromethyl anion equivalent. In this reaction DMF plays a crucial role of stabilisation Trifluoromethyl aryl alcohols, ketones or sulfides can be obtained in good yields with the new reagent CF3H/Base/DMF.

Addition of CFCl3 to aromatic aldehydes via in situ Grignard reaction

Synthetic modification of trichlorofluoromethane (CFCl3) to non-volatile and useful fluorinated precursors is a cost-effective and an environmentally benign strategy for the safe consumption/destruction of the ozone depleting potential of the r

Process of use in perfluoroalkyation and reactant for making use of this process

The subject-matter of the present invention is a process of use in perfluoroalkylation and a reactant for making use of this process. This process is defined in that it comprises a stage in which a material of formula RfH and a base (or a species capable of generating a base) are brought into contact, in a polar and anhydrous medium, with a substrate carrying at least one electrophilic functional group. Application to organic synthesis.

Direct electroreduction or use of an electrogenerated base : Two ways for the coupling of polyhalogenated compounds with aldehydes or ketones

The electrochemical coupling of polyhalogenated compounds with carbonyl compounds is achieved in two ways. A carbanion RX(n)- is generated either by the direct electroreduction of RX(n)Cl or by deprotonation of RX(n)H. In this latter case the base Ph- is electrogenerated by reduction of iodobenzene. All electrolysis were carried out in an undivided cell fitted with a cadmium-coated cathode and an aluminium or magnesium sacrificial anode.