16629-99-5

Upstream product

• 16629-93-9 β-Fluor-α,β,β-trichlorethylbenzol 
• 16629-89-3 2,2-dichloro-2-fluoro-1-phenylethanol 
• 246047-72-3 tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride 
• 79-38-9 Chlorotrifluoroethylene 
• 384-66-7 2,2-dichloro-2-fluoro-1-phenylethanone 
• 431-44-7 methyl 2,2-dichloro-2-fluoroacetate 
• 100-52-7 benzaldehyde 

Relevant academic research and scientific papers

Method for producing fluorine-containing olefin

A method for producing at least one compound selected from the group consisting of a compound represented by formula (10), a compound represented by formula (11), a compound represented by formula (12), and a compound represented by formula (13), by reacting a compound represented by formula (2) and a compound represented by formula (7) in the presence of at least one compound selected from the group consisting of a compound represented by formula (1), a compound represented by formula (3), a compound represented by formula (4), a compound represented by formula (8), and a compound represented by formula (9).

METHOD FOR PRODUCING FLUORINE-CONTAINING OLEFIN

A method for producing at least one compound selected from the group consisting of a compound represented by the following formula (10), a compound represented by the following formula (11), a compound represented by the following formula (12), and a compound represented by the following formula (13), which the method containing reacting a compound represented by the following formula (2) with a compound represented by the following formula (7), in the presence of at least one compound selected from the group consisting of a compound represented by the following formula (1), a compound represented by the following formula (3), a compound represented by the following formula (4), a compound represented by the following formula (8), and a compound represented by the following formula (9).

Synthesis of the multisubstituted halogenated olefins via cross-coupling of dihaloalkenes with alkylzinc bromides

The 1-fluoro-1-haloalkenes undergo Pd-catalyzed Negishi cross-couplings with primary alkylzinc bromides to give multisubstituted fluoroalkenes. The alkylation was trans-selective giving pure Z-fluoroalkenes in most cases. The highest yields were obtained with Pd2(dba)3 and PdCl 2(dppb) catalysts but the best stereochemical outcome was obtained with less reactive Pd(PPh3)4. The tertiary alkylzincs also produced desired fluoroalkenes in high yields. Coupling of β,β- dichlorostyrene with organozinc reagent resulted in the formation of monocoupled product.