Effective nucleophilic trifluoromethylation with fluoroform and common base

DOI: 10.1016/S0040-4020(98)00846-1

Source and publish data:

Tetrahedron p. 13771 - 13782 (1998)

Update date:2022-08-10

Topics:

Authors:

Russell, Jamie

Roques, Nicolas

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Article abstract of DOI:10.1016/S0040-4020(98)00846-1

Common bases (alcoholate, dimsyl anion or amide) are able to deprotonate trifluoromethane to form a trifluoromethyl anion equivalent. In this reaction DMF plays a crucial role of stabilisation Trifluoromethyl aryl alcohols, ketones or sulfides can be obtained in good yields with the new reagent CF₃H/Base/DMF.

Full text of DOI:10.1016/S0040-4020(98)00846-1

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