Effective nucleophilic trifluoromethylation with fluoroform and common base

Article abstract of DOI:10.1016/S0040-4020(98)00846-1

Common bases (alcoholate, dimsyl anion or amide) are able to deprotonate trifluoromethane to form a trifluoromethyl anion equivalent. In this reaction DMF plays a crucial role of stabilisation Trifluoromethyl aryl alcohols, ketones or sulfides can be obtained in good yields with the new reagent CF₃H/Base/DMF.