1664-52-4

Basic information

• Product Name: N-(2-(2-DIETHYLAMINO)ETHYL)-4-NITROBENZAMIDE
• Synonyms: N-(2-(2-DIETHYLAMINO)ETHYL)-4-NITROBENZAMIDE;4-nitroprocainamide;4-Nitro-N-(b-diethylaminoethyl)benzamide
• CAS NO: 1664-52-4
• Molecular Formula: C₁₃H₁₉N₃O₃
• Molecular Weight: 265.31
• Mol File: 1664-52-4.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 437.9°Cat760mmHg
• Flash Point: 218.6°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 7.22E-08mmHg at 25°C
• Refractive Index: 1.546
• CAS DataBase Reference: N-(2-(2-DIETHYLAMINO)ETHYL)-4-NITROBENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-(2-DIETHYLAMINO)ETHYL)-4-NITROBENZAMIDE(1664-52-4)
• EPA Substance Registry System: N-(2-(2-DIETHYLAMINO)ETHYL)-4-NITROBENZAMIDE(1664-52-4)

Safety Data

• Hazardous Substances Data: 1664-52-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C13H19N3O3/c1-3-15(4-2)10-9-14-13(17)11-5-7-12(8-6-11)16(18)19/h5-8H,3-4,9-10H2,1-2H3,(H,14,17)

Upstream product

• 62979-81-1 N-(2-diethylamino-ethyl)-4-nitro-benzamidine; dihydrochloride 
• 122-04-3 4-nitro-benzoyl chloride 
• 100-36-7 N,N-diethylethylenediamine 
• 62-23-7 4-nitro-benzoic acid 
• 555-16-8 4-nitrobenzaldehdye 
• 7291-01-2 N,N-dimethyl-4-nitrobenzamide 
• 619-50-1 4-nitrobenzoic acid methyl ester 

Downstream Products

• 70846-85-4 2-(4-<2-Diethylamino-ethylcarbamoyl>-phenylcarbamoyl)-2-(4-chlor-phenoxy)-propan 
• 51-06-9 4-amino-N-(2-diethylaminoethyl)benzamide 

Relevant articles and documents

-

-

Water-removable ynamide coupling reagent for racemization-free syntheses of peptides, amides, and esters

A novel ynamide coupling reagent, the by-product of which can be removed by water, was reported. It promotes the direct coupling between carboxylic acids and amines, alcohols or thiols to provide amides, peptides, esters and thioesters, respectively. No detectable racemization was observed for all the coupling reactions of carboxylic acids containing an α-chiral center. Importantly, a simple acidic aqueous work-up removed the by-product readily to afford pure coupling products in good to excellent yields without the use of column chromatography, thus making this method more environmentally benign, user friendly and cost-effective. The robustness of the water-removable ynamide coupling reagent was further exemplified by the racemization/epimerization-free synthesis of carfilzomib, in which no column chromatography purification was involved for the entire 12-step synthesis.

Method and using tracer charged ion channel

The invention provides compounds, compositions, methods, and kits for the treatment of pain, itch, and neurogenic inflammation.