1665-59-4

Usage

Uses

Used in Rubber Industry:
N,N-Diethyl-N'-phenylethylenediamine is used as an antioxidant in the rubber industry to prevent or slow down the degradation of rubber materials, thereby extending their service life and maintaining their physical properties.
Used in Plastics Industry:
In the plastics industry, N,N-Diethyl-N'-phenylethylenediamine serves as an antioxidant to protect plastics from oxidative degradation, which can lead to discoloration, embrittlement, and loss of mechanical strength.
Used in Lubricants Industry:
N,N-Diethyl-N'-phenylethylenediamine is used as an antioxidant in lubricants to prevent the oxidation of the base oils, which can cause the formation of sludge, varnish, and other deposits that can lead to equipment failure and reduced performance.

Upstream product

• 858798-55-7 N-(2-diethylamino-ethyl)-formanilide 
• 130862-40-7 N-(2-diethylamino-ethyl)-acetanilide 
• 70249-66-0 N-(2-chloro-ethyl)-toluene-4-sulfonanilide 
• 109-89-7 diethylamine 
• 100-35-6 2-(diethylamino)ethyl chloride 
• 62-53-3 aniline 
• 869-24-9 2-chloro-N,N-diethylethylamine hydrochloride 
• 100-37-8 2-(Diethylamino)ethanol 
• 103-84-4 Acetanilid 
• 103-70-8 Formanilid 
• 13211-05-7 N,N-diethyl-2-(oxy-phenyl-imino)-acetamide 
• 68-34-8 phenyl toluenesulfonamide 
• 586-96-9 Nitrosobenzene 
• 7380-82-7 N,N-diethyl-2-(dimethylsulfuranylidene)acetamide 

Downstream Products

• 857151-30-5 N,N-diethyl-N'-(3-hydroxy-[2]pyridylmethyl)-N'-phenyl-ethylenediamine 
• 858798-55-7 N-(2-diethylamino-ethyl)-formanilide 
• 113061-96-4 [N-(2-diethylamino-ethyl)-anilino]-phenyl-acetonitrile 
• 93151-71-4 N-(2-diethylamino-ethyl)-propionanilide 
• 102007-94-3 N-(2-chloro-phenyl)-N'-(2-diethylamino-ethyl)-N'-phenyl-urea 
• 102875-38-7 N-(2-diethylamino-ethyl)-N,N',N'-triphenyl-urea 
• 5427-46-3 N,N-bis-(2-diethylamino-ethyl)-aniline 
• 92377-08-7 2-[N-(2-diethylamino-ethyl)-anilino]-ethanol 
• 37152-73-1 2-Bromo-N-(2-diethylamino-ethyl)-N-phenyl-propionamide 
• 96524-63-9 [2-(2-Diethylamino-ethylamino)-phenyl]-phenyl-methanone 

Relevant academic research and scientific papers

Halogen bonding enhances activity in a series of dual 5-HT6/D2 ligands designed in a hybrid bioisostere generation/virtual screening protocol

A novel hybrid bioisostere generation/virtual screening method combined with narrowing of chemical space through similarity to compounds that are active at the second target was successfully applied for the development of structurally new dual 5-HT6/D2 receptor ligands. Consequently, a series of derivatives of the found hit 1d (N-[2-(dimethylamino)ethyl]-N-(2-phenylethyl)aniline) was synthesized. The most active 5-HT6/D2 ligands also showed affinity for 5-HT7R and 5-HT2AR. The para-chloroaniline derivative was identified as a potent dual 5-HT6/5-HT7 receptor antagonist (Ki = 24 nM and Kb = 30 nM, Ki = 4 nM and Kb = 1.4 nM, respectively). In the case of halogen-containing compounds, interesting structure-activity relationships were observed at 5-HT6, D2 and 5-HT7 receptors, and the ligand-receptor complexes were subsequently examined using a molecular modelling approach that combined quantum-polarized ligand docking (QPLD) and Molecular-Mechanics-Generalized-Born/Surface Area (MM/GBSA) free-energy calculation, which permitted the identification of putative halogen binding pockets.

Manufacture of arylamines

Arylamines are manufactured by reacting alcohols with amines in the presence of phosphorus-III compounds. The arylamines I manufactured by the process of the invention are intermediates for the manufacture of crop protection agents, optical brighteners, especially amino-coumarin derivatives, and dyes, especially of the xanthene, pyronine, rhodamine, oxazine, azo, triphenylmethane and diphenylmethane series.