16654-56-1

Upstream product

• 7170-42-5 7-phenoxy-heptanoic acid 
• 110-88-3 1,3,5-Trioxan 
• 69687-95-2 ethyl 5-(phenoxy)pentanoate 
• 7170-41-4 6-phenoxyhexanoic acid 
• 10160-24-4 7-bromoheptyl alcohol 
• 108-95-2 phenol 
• 201230-82-2 carbon monoxide 
• 74972-56-8 (hex-5-en-1-yloxy)benzene 
• 16654-54-9 6-phenoxyhexan-1-ol 
• 16654-52-7 5-phenoxy-1-pentanol 
• 7170-40-3 5-phenoxyvaleric acid 
• 82258-47-7 (5-phenoxy-pentyl)-malonic acid diethyl ester 
• 92865-48-0 (5-phenoxy-pentyl)-malonic acid 
• 22921-72-8 (5-bromopentoxy)benzene 

Downstream Products

• 16654-57-2 7-Phenoxy-heptyl-trimethylsilylaether 
• 71933-98-7 dimethyl-(7-phenoxy-heptyl)-amine 
• 51795-98-3 1-bromo-7-phenoxyheptane 

Relevant academic research and scientific papers

Cu-Catalyzed Hydroxymethylation of Unactivated Alkyl Iodides with CO To Provide One-Carbon-Extended Alcohols

We have developed a reductive carbonylation method by which unactivated alkyl iodides can be hydroxymethylated to provide one-carbon-extended alcohol products under Cu-catalyzed conditions. The method is tolerant of alkyl β-hydrogen atoms, is robust towards a wide variety of functional groups, and was applied to primary, secondary, and tertiary alkyl iodide substrates. Mechanistic experiments indicate that the transformation proceeds by atom-transfer carbonylation (ATC) of the alkyl iodide followed in tandem by two CuH-mediated reductions in rapid succession. This radical mechanism renders the Cu-catalyzed system complementary to precious-metal-catalyzed reductive carbonylation reactions.

Tandem hydroformylation/hydrogenation of alkenes to normal alcohols using Rh/Ru dual catalyst or Ru single component catalyst

The catalyst system for tandem hydroformylation/hydrogenation of terminal alkenes to the corresponding homologated normal alcohol was developed. The reaction mechanism for the Rh/Ru dual catalyst was investigated by real-time IR monitoring experiments and 31P NMR spectroscopy, which proved the mutual orthogonality of Rh-catalyzed hydroformylation and Ru-catalyzed hydrogenation. Detailed investigation about Ru-catalyzed hydrogenation of undecanal under H2/CO pressure clarified different kinetics from the hydrogenation under H2 and gave a clue to design more active hydrogenation catalysts under H2/CO atmosphere. The solely Ru-catalyzed normal selective hydroformylation/hydrogenation is also reported.

Inhibitors of bacterial NAD synthetase

The present invention provides methods of synthesizing and screening inhibitors of bacterial NAD synthetase enzyme, compounds thereof, and methods of treating bacterial and microbial infections with inhibitors of bacterial NAD synthetase enzyme.