16656-50-1

Basic information

• Product Name: DIETHYL (ALPHA-AMINOBENZYL)PHOSPHONATE HYDROCHLORIDE
• Synonyms: TIMTEC-BB SBB003023;AURORA KA-1430;DIETHYL (ALPHA-AMINOBENZYL)PHOSPHONATE HYDROCHLORIDE;diethyl (α-aminobenzyl)phosphonate hydrochloride;(Aminophenylmethyl)phosphonic acid diethyl ester hydrochloride;NSC 113536;Phosphonic acid, P-(aminophenylmethyl)-, diethyl ester, hydrochloride (1:1)
• CAS NO: 16656-50-1
• Molecular Formula: C₁₁H₁₈NO₃P*ClH
• Molecular Weight: 279.7
• Product Categories: C-C Bond Formation;Horner-Wadsworth-Emmons Reagents;Olefination
• Mol File: 16656-50-1.mol
• Article Data: 9

Chemical Properties

• Melting Point: 191 °C (dec.)(lit.)
• Boiling Point: 350.6°Cat760mmHg
• Flash Point: 165.8°C
• Appearance: /
• Density: 1.141g/cm³
• Vapor Pressure: 4.36E-05mmHg at 25°C
• CAS DataBase Reference: DIETHYL (ALPHA-AMINOBENZYL)PHOSPHONATE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: DIETHYL (ALPHA-AMINOBENZYL)PHOSPHONATE HYDROCHLORIDE(16656-50-1)
• EPA Substance Registry System: DIETHYL (ALPHA-AMINOBENZYL)PHOSPHONATE HYDROCHLORIDE(16656-50-1)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 16656-50-1(Hazardous Substances Data)

Usage

Uses

Reactant for: Synthesis of phosphonopeptidesreaction with phosphorous pentachloride

Synthesis Reference(s)

Synthesis, p. 763, 1994 DOI: 10.1055/s-1994-25564

InChI:InChI=1/C11H18NO3P.ClH/c1-3-14-16(13,15-4-2)11(12)10-8-6-5-7-9-10;/h5-9,11H,3-4,12H2,1-2H3;1H

Upstream product

• 64244-30-0 diethyl N-benzylidene-1-amino-1-phenylmethylphosphonate 
• 53378-83-9 O,O-diethyl-α-tosyloxybenzylphosphonate 
• 762-04-9 phosphonic acid diethyl ester 
• 92-29-5 hydrobenzamide 
• 100-52-7 benzaldehyde 
• 28867-76-7 benzaldehyde benzylidenehydrazone 
• 122-52-1 triethyl phosphite 
• 135738-78-2 (N-Benzylidenehydrazino)benzyldiphenylphosphine oxide 
• 141330-74-7 Diethyl α-<(2,3,4-Tri-O-pivaloyl-D-arabinopyranosyl)amino>benzylphosphonate 
• 54944-05-7 diethyl α-(2'-benzylidenehydrazino)benzylphosphonate 

Downstream Products

• 81374-44-9 (Phenyl-pyrrol-1-yl-methyl)-phosphonic acid 
• 81374-54-1 1-((E)-3-Methyl-1-phenyl-but-1-enyl)-1H-pyrrole 
• 81374-54-1 1-((E)-3-Methyl-1-phenyl-but-1-enyl)-1H-pyrrole 
• 81374-53-0 1-((E)-1-Phenyl-but-1-enyl)-1H-pyrrole 
• 81374-53-0 1-((E)-1-Phenyl-but-1-enyl)-1H-pyrrole 
• 81374-63-2 (1,2-Diphenyl-1-pyrrol-1-yl-ethyl)-phosphonic acid diethyl ester 
• 81374-40-5 C₁₇H₂₈NO₃PSi₂ 
• 81374-66-5 α-Pyrrolo-α-ethyl-α-phenylmethanphosphonsaeurediethylester 
• 81374-62-1 (1-Phenyl-1-pyrrol-1-yl-ethyl)-phosphonic acid diethyl ester 
• 81374-52-9 1-[(E)-2-(4-Methoxy-phenyl)-1-phenyl-vinyl]-1H-pyrrole 
• 81374-51-8 1-((E)-1,2-Diphenyl-vinyl)-1H-pyrrole 
• 81374-65-4 N-(1-Phenyl-2-methyl-2-ethyl)-vinylpyrrol 
• 35045-98-8 (α-benzoylamino-benzyl)-phosphonic acid 
• 123978-87-0 diethyl N-benzoyl-α-aminobenzyl-phosphonate 

Relevant articles and documents

Comments on a novel synthesis of diethyl 1-aminoarylmethylphosphonates on the surface of alumina

Contrary to the literature statement we found that aromatic aldehydes react with diethyl phosphite and hexamethyldisilazane to give 1-(trimethylsilyloxy)-1-arylmethylphosphonates and not 1-amino-1-arylmethylphosphonate derivatives. Therefore, for preparat

Cholic acid-alpha-amino phosphonate derivative and synthesis method thereof

The invention belongs to the field of medicine chemistry and particularly relates to a cholic acid-alpha-amino phosphonate derivative and a preparation method thereof.Cholic acid and phosphate ester serve as raw materials, and the cholic acid-alpha-amino

Synthesis and solution studies of Cu(II) complexes with pyridine derivatives of iminobisphosphonic acids

New 2-pyridyl, 3-pyridyl and 4-pyridyl derivatives of iminobisphosphonic acid were prepared by addition of tris(trimethylsilyl)phosphite to the corresponding derivatives of pyridineimine-methylphosphonates 3 and subsequent methanolysis of the silylated pr