16656-60-3Relevant academic research and scientific papers
Substituted phosphonic analogues of phenylglycine as inhibitors of phenylalanine ammonia lyase from potatoes
Wanat, Weronika,Talma, Micha?,Hurek, Józef,Pawe?czak, Ma?gorzata,Kafarski, Pawe?
, p. 119 - 127 (2018/06/14)
A series of phosphonic acid analogues of phenylglycine variously substituted in phenyl ring have been synthesized and evaluated for their inhibitory activity towards potato L-phenylalanine ammonia lyase. Most of the compounds appeared to act as moderate (
Inhibitors of phenylalanine ammonialyase: 1-aminobenzylphosphonic acids substituted in the benzene ring
Zoń, Jerzy,Amrhein, Nikolaus,Gancarz, Roman
, p. 9 - 21 (2007/10/03)
Dextrorotatory 1-amino-3′,4′-dichlorobenzylphosphonic acid was found to be a potent inhibitor of the plant enzyme phenylalanine ammonia-lyase both in vitro and in vivo from among the ring-substituted 1-aminobenzylphosphonic acids and other analogues of phenylglycine. A structure activity relationship analysis of the results obtained permits predictions on the geometry of the pocket of the enzyme and is a basis in the strategy of better inhibitor synthesis.
The synthesis of 1-aminobenzylphosphonic acids from benzylidenediphenylmethylamines, for use as structural units in antithrombotic tripeptides
Green, Donovan,Patel, Geeta,Elgendy, Said,Baban, Jehan A.,Claeson, Goran,Kakkar, Vijay V.,Deadman, John
, p. 5099 - 5108 (2007/10/02)
Acid hydrolyses of O,O-dimethyl or O,O-diethyl 1-(diphenylmethylamino) benzylphosphonate intermediates 2, formed from the addition at elevated temperature of dimethyl or diethyl phosphite to benzylidenediphenylmethylamines 1, generates 1-aminobenzylphosphonic acids 3 in good yield.
Studies on Organophosphorus Compounds XXVIII. An Improved Synthetic Route to 1-Amino-Substituted Benzyl Phosphonic and -Phosphinic Acids
Yuan, Chengye,Qi, Youmao
, p. 472 - 474 (2007/10/02)
An improved method for the synthesis of 1-aminosubstituted benzyl phosphonic and -phosphinic acids under mild conditions is described.It consists of the reaction of diphenoxy chlorophosphine (1) or dichlorophenylphosphine (6) with substituted benzaldehyde
An Amidoalkylation of Trivalent Phosphorus Compounds with P(O)H Functions Including Acetic Acid Solutions of PCl3, RPCl2 or R2PCl, Diesters of Phosphorous Acid and Phosphorus-III-Acids
Oleksyszyn, Jozef
, p. 19 - 28 (2007/10/02)
An amidoalkylation of PCl3 or its organic derivatives in acetic acid solution takes place because equilibrium between AcOH and >P-Cl exist, leading to hydroxychlorophosphines.Those last compounds undergo an amidoalkylation like other nucleophiles.Based on these data, it was shown that an amidoalkylation reaction is usual for all phosphorus compounds with the R2P(O)H system and provides derivatives with the >N-C-P(O)R2 functions.The scope and limitation of these reactions are discussed.
