1666-19-9Relevant academic research and scientific papers
α-Tosyloxylation of ketones with ion-supported[hydroxy(tosyloxy)iodo] benzene
Su, Feng,Zhang, Jizhen,Jin, Guangyu,Qiu, Tao,Zhao, Dejian,Jia, Hongbin
, p. 741 - 744 (2009)
A new room-temperature ionic liquid (RTIL) supported [hydroxy(tosyloxy) iodo]benzene (ion-supported HTIB) reagent was synthesised by three kinds of effective methods in high yields, which combined the advantages of ionic liquids and the hypervalent iodine
α-Tosyloxylation of fluorosubstituted β-diketones
Ratner, V. G.,Pashkevich, K. I.
, p. 501 - 502 (1994)
The interaction of fluorinated β/diketones with benzene leads to α-tosyloxy-β-diketones existing in the form of stable hydrates. - Key words: fluorosubstituted β-diketones; α-tosyloxylation; de(perfluoroacyl)ation.
Oxa-[3+3] annulation of MBH-carbonates of propiolaldehydes with α-nitro/bromo ketones to access 2: H -pyrans
Reddy, Chada Raji,Patil, Amol D.,Mohammed, Siddique Z.
supporting information, p. 7191 - 7194 (2020/07/14)
A novel alkyne-assisted annulation reaction of MBH-carbonates of propiolaldehydes with α-nitro/bromo ketones is reported, providing a facile synthesis of substituted 2H-pyrans in good yields. This reaction divulges the inimitable reactivity of the MBH-carbonates of propiolaldehydes as C3-synthons wherein the alkyne functionality promoted the reaction without participating in the oxa-[3+3] annulation. The obtained products, having alkyne and ester functionalities, allowed further annulations to generate diverse pyrano[3,4-c]pyran-1-ones. This journal is
2-AMINO-QUINOLINE DERIVATIVES
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Paragraph 0174; 0211-0212, (2018/11/22)
Described herein are 2-amino-quinoline derivatives that are agonists of toll-like receptors 7 and 8 (TLR7/8), pharmaceutical compositions, and methods of use of the compounds and compositions to treat various diseases, such as viral, cancer, and allergic diseases, in need thereof by administering a therapeutically effective amount of a 2-amino-quinoline derivative.
Novel α-tosyloxylation of ketones catalyzed by the in situ generated hypoiodous acid from alkyl iodide
Zhang, Bijun,Han, Liuquan,Hu, Jiantao,Yan, Jie
, p. 5851 - 5854 (2015/01/16)
Using a catalytic amount of 1-iodopropane, a novel and efficient procedure has been developed for direct preparation of α-tosyloxyketones from ketones. In this protocol, 1-iodopropane is first oxidized into iodosylpropane, which decomposes to form the key
Effective α-tosyloxylation of ketones using 1,1,1-trifluoro-2-iodoethane as catalyst
Zhang, Bijun,Han, Liuquan,Hu, Jiantao,Yan, Jie
supporting information, p. 3264 - 3270 (2015/10/06)
With 1,1,1-trifluoro-2-iodoethane as catalyst, a novel and efficient procedure has been developed for preparation of α-tosyloxyketones from ketones. In this protocol, 1,1,1-trifluoro-2-iodoethane is first oxidized by m-chloroperbenzoic acid to a hypervale
Templated carbene metathesis reactions from the modular assembly of enol-diazo compounds and propargyl acetates
Qian, Yu,Shanahan, Charles S.,Doyle, Michael P.
supporting information, p. 6032 - 6037 (2013/09/24)
A Lewis acid mediated coupling reaction of enol-diazo nucleophiles and propargyl acetates has provided rapid and diverse access to complex alkynyl-tethered diazocarbonyl compounds. The ability of the coupling reaction to vary critical functionality flanking the diazo group was explored as a way to direct the outcome of a series of metal-catalyzed carbene metathesis cascade reactions. These cascade reactions provided diverse, biologically interesting carbocyclic and heterocyclic compounds in only a few steps from readily available materials. A general coupling strategy for the formation of alkynyl-substituted diazocarbonyl templates for catalytic cascade reactions is described. With the synthetic flexibility imparted to the coupling process and the facile cyclization of the first-formed metal carbene to secondary vinyl carbene templates, selective ylide, C-H insertion, and atom-transfer processes provide directed functionalization in cyclic compounds.
A novel one-pot method for αα-tosyloxylation of ketones using a catalytic amount of ammonium iodide
Hu, Jiantao,Zhu, Min,Xu, Yuan,Yan, Jie
experimental part, p. 1226 - 1232 (2012/05/20)
A novel one-pot procedure was designed for the preparation of various α-tosyloxy ketones in good yields by the reaction of ketones with m-chloroperoxybenzoic acid and p-toluenesulfonic acid monohydrate in the presence of catalytic amounts of ammonium iodi
One-Pot Protocol for Synthesis of -Organosulfonyloxy Ketones from Secondary Alcohols Using Hypervalent Iodine(V)-Mediated Oxidations
Deshmukh, Swapnil S.,Huddar, Sameerana N.,Akamanchi, Krishnacharya G.
experimental part, p. 3101 - 3110 (2009/11/30)
Tosyloxy ketones and -mesyloxy ketones were directly prepared from alcohols in one pot by treatment with hypervalent iodine(V) reagents in combination with p-toluenesulfonic acid and methanesulfonic acid, respectively, in moderate to good yields. Reaction
M-iodosylbenzoic acid: Recyclable hypervalent iodine reagent for-tosyloxylation and-mesyloxylation of ketones
Yusubov, Mekhman S.,Funk, Tatyana V.,Yusubova, Roza Y.,Zholobova, Galina,Kirschning, Andreas,Park, Joo Yeon,Chi, Ki-Whan
experimental part, p. 3772 - 3784 (2009/12/06)
m-Iodosylbenzoic acid-mediated reactions of various carbonyl compounds provided-organosulfonyloxy carbonyl compounds in good yields. The final products could be easily isolated without any chromatographic purification by simple treatment of the crude mixt
