1666-85-9

Usage

Uses

Used in Pharmaceutical and Biological Research:
1,3,4-Triphenyl-1H-pyrazole is used as a building block in the synthesis of other organic compounds for pharmaceutical and biological research. Its unique structure and properties make it a valuable component in the development of new drugs with potential therapeutic applications.
Used in Fluorescent Sensor Development:
1,3,4-Triphenyl-1H-pyrazole is known for its ability to exhibit fluorescence, making it a useful component in the development of fluorescent sensors. These sensors can be designed to detect metal ions, which have various applications in research, environmental monitoring, and other fields.
Used in Organic Synthesis:
1,3,4-Triphenyl-1H-pyrazole is used as a key intermediate in the synthesis of various organic compounds. Its versatile structure allows for the creation of a wide range of molecules with different properties and potential applications in various industries.

InChI:InChI=1/C21H16N2/c1-4-10-17(11-5-1)20-16-23(19-14-8-3-9-15-19)22-21(20)18-12-6-2-7-13-18/h1-16H

Upstream product

• 501-65-5 diphenyl acetylene 
• 508191-77-3 3-phenylsydnone 
• 21306-38-7 7-phenyl-1,7-diaza-bicyclo<2.2.1>heptane-exo-2,3-exo-5,6-tetracarboxylic acid bisphenylimide 
• 21306-38-7 7-phenyl-1,7-diaza-bicyclo<2.2.1>heptane-endo-2,3-exo-5,6-tetracarboxylic acid bisphenylimide 
• 77987-92-9 Phenyl-(2,4,5-triphenyl-3,4-dihydro-2H-pyrazol-3-yl)-methanone oxime 
• 475094-43-0 5-(methylthio)-1,3,4-triphenyl-1H-pyrazole 
• 51507-11-0 3,3-bis(methylthio)-1,2-diphenylprop-2-en-1-one 
• 100-63-0 phenylhydrazine 
• 614-47-1 1,3-diphenyl-propen-3-one 
• 1190837-94-5 4-bromo-1-phenyl-1H-pyrazol-3-yl trifluoro methanesulfonate 
• 98-80-6 phenylboronic acid 
• 1296269-70-9 4-iodo-5-(methylthio)-1,3-diphenyl-1H-pyrazole 
• 66040-87-7 1,3-diphenyl-5-(methylthio)-1H-pyrazole 
• 32859-25-9 4-bromo-5-(methylthio)-1,3-diphenyl-1H-pyrazole 

Relevant academic research and scientific papers

Copper-catalyzed synthesis of 1,3,4-trisubstituted and 1,3,4,5-tetrasubstituted pyrazoles via [3+2] cycloadditions of hydrazones and nitroolefins

A highly economical and efficient copper(I)-catalyzed regioselective method for the synthesis of 1,3,4-trisubstituted and 1,3,4,5-tetrasubstituted pyrazoles via [3+2] cycloaddition of hydrazones and nitroolefins has been reported. This process displays excellent applicability with a wide range of substrates under mild conditions.

Synthesis of 3H-pyrazolo[3,4-c]isoquinolines and thieno[3,2-c]isoquinolines via cascade imination/intramolecular decarboxylative coupling

A general approach for the synthesis of 3H-pyrazolo[3,4-c]isoquinolines and thieno[3,2-c]isoquinolines is described involving the implementation of a cascade imination/intramolecular decarboxylative coupling between potassium 2-amino(hetero)benzoates and 2-haloarylaldehydes. The reactions of pyrazole-based substrates require a Pd-Cu bimetallic system for superior yields whereas the thienyl-based substrates afford the products in excellent yields with a Pd-catalyst only.

Regioselective rapid analog synthesis of 1,3-(or 1,5-)diphenyl-4-aryl/ heteroaryl-5-(or 3-)(methylthio)pyrazoles via Suzuki cross-coupling

Regioselective routes for the synthesis of 1,3-(or 1,5-)diphenyl-4-aryl/ heteroaryl-5-(or 3-)(methylthio)pyrazoles via Suzuki cross-coupling of 4-bromo (or 4-iodo)-1,3-(or 1,5-)diphenyl-5-(or 3-)(methylthio)pyrazoles have been reported.

Cu(OAc)2·H2O-catalyzed N-arylation of nitrogen-containing heterocycles

In the absence of any additional ligands, the efficient N-arylation of nitrogen-containing heterocycles with aryl iodides catalyzed by relative low catalyst amount of Cu(OAc)2·H2O was developed. This simple catalytic system is involved in the C-N cross-coupling reaction and works for a variety of pyrazole, pyrrole, imidazole, triazole, indole, benzoimidazole, benzotriazole, carbazole, and anilines as well as aryl iodides with different electronic properties. Highly efficient copper(II)-catalyzed N-arylation protocol was established.

Pd-catalyzed cross-coupling reactions of halogenated 1-phenylpyrazol-3-ols and related triflates

1-Phenyl-1H-pyrazol-3-ol was used as a versatile synthon for the preparation of various 1-phenyl-1H-pyrazole derivatives substituted at C-3 and C-4 of the pyrazole nucleus and at the phenyl ring para-position. Treatment of 1-phenyl-1H-pyrazol-3-ol with tr

Regioselective synthesis of 1-aryl-3,4-substituted/annulated-5-(methylthio) pyrazoles and 1-aryl-3-(methylthio)-4,5-substituted/annulated pyrazoles

Highly efficient and regioselective synthesis of 1-aryl-3,4-substituted/ annulated-5-(methylthio)-pyrazoles and 1-aryl-3-(methylthio)-4,5-substituted/ annulated pyrazoles has been reported via cyclocondensation of arylhydrazines with either α-oxoketene dithioacetals or β-oxodithioesters.

REPLACEMENT OF DIPOLAROPHILE OF 1,3-CYCLOADDUCT

Novel double 1,3-cycloreversion and the replacement of dipolarophile of the bisadducts of 3-phenyl sydnone and N-phenylmaleimide are described.