1668-01-5

Basic information

• Product Name: 3,4-Dichloro-1,2-benzenediamine
• Synonyms: 3,4-Dichloro-1,2-benzenediamine;3,4-dichlorobenzene-1,2-diamine
• CAS NO: 1668-01-5
• Molecular Formula: C₆H₆Cl₂N₂
• Molecular Weight: 177.03
• EINECS: 604-604-1
• Mol File: 1668-01-5.mol
• Article Data: 9

Chemical Properties

• Melting Point: 82-83 °C
• Boiling Point: 321.1±37.0 °C(Predicted)
• Appearance: /
• Density: 1.501±0.06 g/cm3(Predicted)
• PKA: 2.47±0.10(Predicted)
• CAS DataBase Reference: 3,4-Dichloro-1,2-benzenediamine(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-Dichloro-1,2-benzenediamine(1668-01-5)
• EPA Substance Registry System: 3,4-Dichloro-1,2-benzenediamine(1668-01-5)

Safety Data

• Hazardous Substances Data: 1668-01-5(Hazardous Substances Data)

Usage

General Description

3,4-Dichloro-1,2-benzenediamine, a chemical compound also known as 3,4-dichloro-o-phenylenediamine, is a synthetic aromatic amine with two chlorine atoms attached to a benzene ring. It is primarily used as an intermediate in the production of dyes, hair dyes, and photographic developers. It is also utilized in the manufacturing of pharmaceuticals and agrochemicals. However, 3,4-dichloro-1,2-benzenediamine is known to be a skin and respiratory irritant, as well as a potential allergen, and is classified as a hazardous substance with strict regulations for its handling and use in industrial settings. 3,4-Dichloro-1,2-benzenediamine is considered potentially harmful to the environment and human health, and caution is advised when working with or being exposed to it.

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Relevant articles and documents

Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice

Cyclic GMP-AMP synthase is essential for innate immunity against infection and cellular damage, serving as a sensor of DNA from pathogens or mislocalized self-DNA. Upon binding double-stranded DNA, cyclic GMP-AMP synthase synthesizes a cyclic dinucleotide that initiates an inflammatory cellular response. Mouse studies that recapitulate causative mutations in the autoimmune disease Aicardi-Goutières syndrome demonstrate that ablating the cyclic GMP-AMP synthase gene abolishes the deleterious phenotype. Here, we report the discovery of a class of cyclic GMP-AMP synthase inhibitors identified by a high-throughput screen. These compounds possess defined structure-activity relationships and we present crystal structures of cyclic GMP-AMP synthase, double-stranded DNA, and inhibitors within the enzymatic active site. We find that a chemically improved member, RU.521, is active and selective in cellular assays of cyclic GMP-AMP synthase-mediated signaling and reduces constitutive expression of interferon in macrophages from a mouse model of Aicardi-Goutières syndrome. RU.521 will be useful toward understanding the biological roles of cyclic GMP-AMP synthase and can serve as a molecular scaffold for development of future autoimmune therapies.

NOVEL COMPOUNDS USEFUL AS S100-INHIBITORS

A compound of formula (I) or a pharmaceutically acceptable salt thereof and a pharmaceutical composition comprising the compound. The compound is an inhibitor of interactions between S100A9 and interaction partners such as RAGE, TLR4 and EMMPRIN and as such is useful in the treatment of disorders such as cancer, autoimmune disorders, inflammatory disorders and neurodegenerative disorders.

Synthesis and evaluation for biological activity of 3-alkyl and 3-halogenoalkyl-quinoxalin-2-ones variously substituted. Part 4

A new series of 3-isopropyl-, 3-trifluoromethyl- and 3-bromomethylquinoxaline-2-ones variously substituted on the benzo-moiety were synthesized and submitted to a preliminary in vitro evaluation for antibacterial, antifungal and anti-HIV activities. Furth