65078-77-5

Basic information

• Product Name: 2,3-dichloro-6-nitroaniline
• Synonyms: 2,3-Dichloro-6-nitrobenzenamine
• CAS NO: 65078-77-5
• Molecular Formula: C₆H₄Cl₂N₂O₂
• Molecular Weight: 207.01
• EINECS: 265-378-3
• Mol File: 65078-77-5.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 323.5 °C at 760 mmHg
• Flash Point: 149.4 °C
• Appearance: /
• Density: 1.624 g/cm³
• Vapor Pressure: 0.000261mmHg at 25°C
• Refractive Index: 1.655
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 2,3-dichloro-6-nitroaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-dichloro-6-nitroaniline(65078-77-5)
• EPA Substance Registry System: 2,3-dichloro-6-nitroaniline(65078-77-5)

Safety Data

• Hazardous Substances Data: 65078-77-5(Hazardous Substances Data)

Usage

General Description

2,3-dichloro-6-nitroaniline is a chemical compound with the molecular formula C6H4Cl2N2O2. It is a yellow solid and is used primarily as an intermediate in the production of dyes and pigments. It is also used in the synthesis of pharmaceuticals and organic compounds. 2,3-dichloro-6-nitroaniline is considered to be toxic and harmful if ingested, inhaled, or absorbed through the skin. It may cause irritation to the skin, eyes, and respiratory system, and prolonged exposure can have detrimental effects on human health. Therefore, proper precautions should be taken when handling and using this chemical.

InChI:InChI=1/C6H4Cl2N2O2/c7-3-1-2-4(10(11)12)6(9)5(3)8/h1-2H,9H2

Upstream product

• 17700-09-3 4-nitro-1,2,3-trichlorobenzene 
• 99-54-7 3,4-dichloronitrobenzene 
• 87-61-6 1,2,3-trichlorobenzene 
• 23068-36-2 N-(2,3-dichlorophenyl)-acetamide 
• 608-27-5 2,3-dichloroaniline 
• 7664-41-7 ammonia 
• 6327-47-5 2,3-dichloroformanilide 
• 65078-76-4 2,3-dichloro-6-nitroacetanilide 

Downstream Products

• 717108-60-6 2-chloro-3-morpholino-6-nitroaniline 
• 173460-79-2 2-bromo-4,5-dichlorobenzimidazole 
• 173460-82-7 1-(2-Benzyloxy-ethoxymethyl)-2,4,5-trichloro-1H-benzoimidazole 
• 173461-08-0 1-(2-Benzyloxy-1-benzyloxymethyl-ethoxymethyl)-2,4,5-trichloro-1H-benzoimidazole 
• 74070-47-6 2-Chloro-3-phenylthio-6-nitroaniline 
• 2262452-06-0 3-[1-(6,7-dichloro-1H-benzimidazol-2-yl)-5-hydroxy-3-methyl-pyrazol-4-yl]-3H-isobenzofuran-1-one 
• 1668-01-5 3,4-dichloro-1,2-phenylenediamine 
• 74070-46-5 aclonifen 
• 95-76-1 m,p-dichloroaniline 
• 1378864-94-8 1,2-diamino-3-chloro-4-methoxybenzene 
• 717108-61-7 3-chloro-4-morpholino-1,2-diaminobenzene 
• 89975-38-2 2-chloro-3-methoxy-6-nitroaniline 
• 65078-76-4 2,3-dichloro-6-nitroacetanilide 
• 20039-23-0 1,2-dichloro-3,4-dinitrobenzene 

Relevant articles and documents

Preparation method of 3, 4-dichloro-2-fluoroaniline

The invention discloses a preparation method of 3, 4-dichloro-2-fluoroaniline, which comprises the following steps: (1) taking 1, 2, 3-trichlorobenzene as a raw material, and carrying out nitration reaction to obtain 2, 3, 4-trichloronitrobenzene; (2) the 2, 3, 4-trichloronitrobenzene is subjected to an ammonolysis reaction, and 2, 3-dichloro-6-nitroaniline is obtained; (3) carrying out diazotization reaction on the 2, 3-dichloro-6-nitroaniline, fluorine-containing inorganic acid and sodium nitrite in an organic solvent to generate diazonium salt, and then heating and decomposing to obtain 2-fluoro-3, 4-dichloronitrobenzene; and (4) reducing the 2-fluoro-3, 4-dichloronitrobenzene, so as to obtain the 3, 4-dichloro-2-fluoroaniline. According to the method, 1, 2, 3-trichlorobenzene serves as a raw material, and 3, 4-dichloro-2-fluoroaniline is obtained through the processes of nitration, ammonolysis, diazotization, decomposition, reduction and the like; the method provides a synthetic route of 3, 4-dichloro-2-fluoroaniline, and has the characteristics of simple process, easily controlled process, high product yield, high purity, low production cost and the like.

2, 3-dichloro-6-nitroaniline and preparation method thereof

Belonging to the field of organic synthesis, the invention relates to 2, 3-dichloro-6-nitroaniline and a preparation method thereof. According to the invention, 2, 3-dichloro-6-nitroaniline is prepared by a two-step method. The method includes: firstly taking 1, 2, 3-trichlorobenzene as the raw material to carry out nitration reaction with nitric acid in a sulfuric acid system to prepare 2, 3, 4-trichloronitrobenzene; and then carrying out ammonolysis reaction on the 2, 3, 4-trichloronitrobenzene and ammonia water in an organic solvent at 120-150DEG C so as to obtain DCONA. The preparation method has the advantages of simple operation, mild reaction conditions, high yield and purity, and green and environment protection, and the sulfuric acid, organic solvent and ammonia water used in the preparation process can all be effectively recovered.

CARBONYL LINKED BICYCLIC HETEROARYL N-BENZIMIDAZOLES AND ANALOGS AS ANTIBIOTIC TOLERANCE INHIBITORS

The disclosure provides compounds and pharmaceutical compositions of includes carbonyl linked bicyclic heteroaryl N-benzimidazole compounds useful for treating chronic and acute bacterial infections. Certain of the compounds are compounds of general Formula (I) or a pharmaceutically acceptable salt or prodrug thereof. Certain compounds of this disclosure are MvfR inhibitors. MvfR inhibitors reduce the formation of antibiotic tolerant bacterial strains and are useful for treating Gram-negative bacterial infections and reducing the virulence of Pseudomonas aeruginosa. Methods of treating bacterial infections in a subject, including Pseudomonas aeruginosa infections, are also provided by the disclosure.